Personalized medicine approaches to the prevention, diagnosis, and treatment of chronic periodontitis

Carlos Garaicoa-Pazmino, Ann M. Decker, Peter J. Polverini

Research output: Chapter in Book/Report/Conference proceedingChapter

4 Scopus citations

Abstract

Over the years, the multifactorial and interactive nature of periodontal disease challenged clinicians in an attempt to delineate a pattern for its destructive progression. Periodontal disease is caused by persistent infl ammation of the periodontium in response to the colonization of microbes upon the tooth surface near the gingival margin and a subsequent biofi lm formation resulting in irreversible attachment loss of marginal alveolar bone and associated periodontal ligament and migration of the junctional epithelium. In spite of the infectious nature of periodontal disease, identifi cation of the oral microbiome and a complete understanding of its pathogenic pathway seem the most logical step toward the development of newer and effective approaches for periodontal therapy.

Original languageEnglish (US)
Title of host publicationPersonalized Oral Health Care
Subtitle of host publicationFrom Concept Design to Clinical Practice
PublisherSpringer International Publishing
Pages99-112
Number of pages14
ISBN (Electronic)9783319232973
ISBN (Print)9783319232966
DOIs
StatePublished - Jan 1 2016
Externally publishedYes

Keywords

  • Epigenetics
  • Gingivitis
  • Microbiome
  • Periodontitis
  • Personalized dentistry
  • Risk factors

ASJC Scopus subject areas

  • Dentistry(all)
  • Medicine(all)

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