Persistent versus transient stimulation of the macaque corpus luteum during prolonged exposure to human chorionic gonadotropin: A function of age of the corpus luteum

J. S. Ottobre, Richard Stouffer

Research output: Contribution to journalArticle

41 Citations (Scopus)

Abstract

The rescue of the primate corpus luteum (CL) by CG in early pregnancy is transient, despite a continued rise in circulating CG. To investigate the mechanism resulting in this response, female rhesus monkeys were given im injections of increasing doses of hCG for 10 days during the menistrual cycle to mimic that pattern of circulating macaque CG observed in early pregnancy. Treatment began 5.3 ± 0.3 (early luteal phase; n = 4; mean ± SE), 8.3 ± 0.5 (midluteal phase; n = 6), or 12.0 ± 0.4 (late luteal phase; n = 4) days after the midcycle LH surge. Femoral venous blood was collected daily from CG-treated animals from day 8 of the menstrual cycle until the onset of menses. Serum hCG, LH, progesterone (P), and 17β-estradiol (E) were measured by RIA. When CG treatment began during the early luteal phase, serum P increased within 9 h after the initial injection (P

Original languageEnglish (US)
Pages (from-to)2175-2182
Number of pages8
JournalEndocrinology
Volume114
Issue number6
StatePublished - 1984
Externally publishedYes

Fingerprint

Luteal Phase
Corpus Luteum
Macaca
Chorionic Gonadotropin
Pregnancy
Injections
Menstruation
Menstrual Cycle
Thigh
Macaca mulatta
Serum
Primates
Progesterone
Estradiol
Therapeutics

ASJC Scopus subject areas

  • Endocrinology
  • Endocrinology, Diabetes and Metabolism

Cite this

@article{e85caa3c04c74bffa4e4d4f291ebf903,
title = "Persistent versus transient stimulation of the macaque corpus luteum during prolonged exposure to human chorionic gonadotropin: A function of age of the corpus luteum",
abstract = "The rescue of the primate corpus luteum (CL) by CG in early pregnancy is transient, despite a continued rise in circulating CG. To investigate the mechanism resulting in this response, female rhesus monkeys were given im injections of increasing doses of hCG for 10 days during the menistrual cycle to mimic that pattern of circulating macaque CG observed in early pregnancy. Treatment began 5.3 ± 0.3 (early luteal phase; n = 4; mean ± SE), 8.3 ± 0.5 (midluteal phase; n = 6), or 12.0 ± 0.4 (late luteal phase; n = 4) days after the midcycle LH surge. Femoral venous blood was collected daily from CG-treated animals from day 8 of the menstrual cycle until the onset of menses. Serum hCG, LH, progesterone (P), and 17β-estradiol (E) were measured by RIA. When CG treatment began during the early luteal phase, serum P increased within 9 h after the initial injection (P",
author = "Ottobre, {J. S.} and Richard Stouffer",
year = "1984",
language = "English (US)",
volume = "114",
pages = "2175--2182",
journal = "Endocrinology",
issn = "0013-7227",
publisher = "The Endocrine Society",
number = "6",

}

TY - JOUR

T1 - Persistent versus transient stimulation of the macaque corpus luteum during prolonged exposure to human chorionic gonadotropin

T2 - A function of age of the corpus luteum

AU - Ottobre, J. S.

AU - Stouffer, Richard

PY - 1984

Y1 - 1984

N2 - The rescue of the primate corpus luteum (CL) by CG in early pregnancy is transient, despite a continued rise in circulating CG. To investigate the mechanism resulting in this response, female rhesus monkeys were given im injections of increasing doses of hCG for 10 days during the menistrual cycle to mimic that pattern of circulating macaque CG observed in early pregnancy. Treatment began 5.3 ± 0.3 (early luteal phase; n = 4; mean ± SE), 8.3 ± 0.5 (midluteal phase; n = 6), or 12.0 ± 0.4 (late luteal phase; n = 4) days after the midcycle LH surge. Femoral venous blood was collected daily from CG-treated animals from day 8 of the menstrual cycle until the onset of menses. Serum hCG, LH, progesterone (P), and 17β-estradiol (E) were measured by RIA. When CG treatment began during the early luteal phase, serum P increased within 9 h after the initial injection (P

AB - The rescue of the primate corpus luteum (CL) by CG in early pregnancy is transient, despite a continued rise in circulating CG. To investigate the mechanism resulting in this response, female rhesus monkeys were given im injections of increasing doses of hCG for 10 days during the menistrual cycle to mimic that pattern of circulating macaque CG observed in early pregnancy. Treatment began 5.3 ± 0.3 (early luteal phase; n = 4; mean ± SE), 8.3 ± 0.5 (midluteal phase; n = 6), or 12.0 ± 0.4 (late luteal phase; n = 4) days after the midcycle LH surge. Femoral venous blood was collected daily from CG-treated animals from day 8 of the menstrual cycle until the onset of menses. Serum hCG, LH, progesterone (P), and 17β-estradiol (E) were measured by RIA. When CG treatment began during the early luteal phase, serum P increased within 9 h after the initial injection (P

UR - http://www.scopus.com/inward/record.url?scp=0021267288&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=0021267288&partnerID=8YFLogxK

M3 - Article

C2 - 6723578

AN - SCOPUS:0021267288

VL - 114

SP - 2175

EP - 2182

JO - Endocrinology

JF - Endocrinology

SN - 0013-7227

IS - 6

ER -