Persistent electrical coupling and locomotory dysfunction in the zebrafish mutant shocked

Victor M. Luna, Meng Wang, Fumihito Ono, Michelle R. Gleason, Julia E. Dallman, Gail Mandel, Paul Brehm

Research output: Contribution to journalArticle

19 Citations (Scopus)

Abstract

On initial formation of neuromuscular junctions, slow synaptic signals interact through an electrically coupled network of muscle cells. After the developmental onset of muscle excitability and the transition to fast synaptic responses, electrical coupling diminishes. No studies have revealed the functional importance of the electrical coupling or its precisely timed loss during development. In the mutant zebrafish shocked (sho) electrical coupling between fast muscle cells persists beyond the time that it would normally disappear in wild-type fish. Recordings from sho indicate that muscle depolarization in response to motor neuron stimulation remains slow due to the low-pass filter characteristics of the coupled network of muscle cells. Our findings suggest that the resultant prolonged muscle depolarizations contribute to the premature termination of swimming in sho and the delayed acquisition of the normally rapid touch-triggered movements. Thus the benefits of gap junctions during early synapse development likely become a liability if not inactivated by the time that muscle would normally achieve fast autonomous function.

Original languageEnglish (US)
Pages (from-to)2003-2009
Number of pages7
JournalJournal of Neurophysiology
Volume92
Issue number4
DOIs
StatePublished - Oct 2004
Externally publishedYes

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Zebrafish
Muscle Cells
Muscles
Neuromuscular Junction
Gap Junctions
Touch
Motor Neurons
Synapses
Fishes

ASJC Scopus subject areas

  • Physiology
  • Neuroscience(all)

Cite this

Persistent electrical coupling and locomotory dysfunction in the zebrafish mutant shocked. / Luna, Victor M.; Wang, Meng; Ono, Fumihito; Gleason, Michelle R.; Dallman, Julia E.; Mandel, Gail; Brehm, Paul.

In: Journal of Neurophysiology, Vol. 92, No. 4, 10.2004, p. 2003-2009.

Research output: Contribution to journalArticle

Luna, Victor M. ; Wang, Meng ; Ono, Fumihito ; Gleason, Michelle R. ; Dallman, Julia E. ; Mandel, Gail ; Brehm, Paul. / Persistent electrical coupling and locomotory dysfunction in the zebrafish mutant shocked. In: Journal of Neurophysiology. 2004 ; Vol. 92, No. 4. pp. 2003-2009.
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