In a phase I HIV vaccine trial, Basu et al. show the robust response of HIV Env gp120-specific peripheral blood plasmablasts immediately after vaccination, dominated by VH1 gene usage and V3 region-targeting Abs. They also define persistent linkage of these Env-reactive lineages to the bone marrow CD138+ LLPC compartment.
- B cell
- bone marrow
- plasma cell
ASJC Scopus subject areas
- Biochemistry, Genetics and Molecular Biology(all)