Persistence of HIV-1 Env-Specific Plasmablast Lineages in Plasma Cells after Vaccination in Humans

Madhubanti Basu, Michael S. Piepenbrink, Czestochowa Francois, Fritzlaine Roche, Bo Zheng, David A. Spencer, Ann J. Hessell, Christopher F. Fucile, Alexander F. Rosenberg, Catherine A. Bunce, Jane Liesveld, Michael C. Keefer, James J. Kobie

Research output: Contribution to journalArticlepeer-review

2 Scopus citations

Abstract

In a phase I HIV vaccine trial, Basu et al. show the robust response of HIV Env gp120-specific peripheral blood plasmablasts immediately after vaccination, dominated by VH1 gene usage and V3 region-targeting Abs. They also define persistent linkage of these Env-reactive lineages to the bone marrow CD138+ LLPC compartment.

Original languageEnglish (US)
Article number100015
JournalCell Reports Medicine
Volume1
Issue number2
DOIs
StatePublished - May 19 2020
Externally publishedYes

Keywords

  • B cell
  • HIV-1
  • antibody
  • bone marrow
  • envelope
  • plasma cell
  • repertoire
  • vaccine

ASJC Scopus subject areas

  • Biochemistry, Genetics and Molecular Biology(all)
  • Medicine(all)

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