Persistence of HIV-1 Env-Specific Plasmablast Lineages in Plasma Cells after Vaccination in Humans

Madhubanti Basu, Michael S. Piepenbrink, Czestochowa Francois, Fritzlaine Roche, Bo Zheng, David A. Spencer, Ann J. Hessell, Christopher F. Fucile, Alexander F. Rosenberg, Catherine A. Bunce, Jane Liesveld, Michael C. Keefer, James J. Kobie

    Research output: Contribution to journalArticlepeer-review

    1 Scopus citations

    Abstract

    In a phase I HIV vaccine trial, Basu et al. show the robust response of HIV Env gp120-specific peripheral blood plasmablasts immediately after vaccination, dominated by VH1 gene usage and V3 region-targeting Abs. They also define persistent linkage of these Env-reactive lineages to the bone marrow CD138+ LLPC compartment.

    Original languageEnglish (US)
    Article number100015
    JournalCell Reports Medicine
    Volume1
    Issue number2
    DOIs
    StatePublished - May 19 2020

    Keywords

    • B cell
    • HIV-1
    • antibody
    • bone marrow
    • envelope
    • plasma cell
    • repertoire
    • vaccine

    ASJC Scopus subject areas

    • Biochemistry, Genetics and Molecular Biology(all)
    • Medicine(all)

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