Persistant effects of amphetamine on cerebellar Purkinje neurons following chronic administration

Stephen M. Sorensen, Steven W. Johnson, Robert Freedman

Research output: Contribution to journalArticle

17 Scopus citations

Abstract

The spontaneous discharge of cerebellar Purkinje neurons was studied in rats after withdrawal from chronic treatment with amphetamine (2 mg/kg per day × 21 days). Discharge rates in withdrawn animals remained significantly lower than those of controls for up to 50 days. Disruption of the adrenergic input to these neurons from the locus coeruleus by treatment with propranolol, clonidine or reserpine, partially restored these discharge rates. Acute administration of amphetamine in amphetamine-withdrawn rats did not further depress Purkinje neuron discharge rate, whereas in a previous study in this lab, Purkinje neurons from naive animals were markedly slowed. Moreover, Purkinje neurons from amphetamine-withdrawn rats were also significantly less sensitive than controls to locally applied norepinephrine. These results demonstrate that chronic amphetamine can lead to very long-term changes in neuronal activity, and suggest that these changes may be mediated, in part, by the noradrenergic transmitter systems.

Original languageEnglish (US)
Pages (from-to)365-371
Number of pages7
JournalBrain research
Volume247
Issue number2
DOIs
StatePublished - Sep 16 1982

Keywords

  • amphetamine
  • cerebellum
  • norepinephrine
  • withdrawal

ASJC Scopus subject areas

  • Neuroscience(all)
  • Molecular Biology
  • Clinical Neurology
  • Developmental Biology

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