Permeability of placenta to inulin

Kent Thornburg, K. J. Burry, A. King Adams, E. P. Kirk, J. J. Faber

    Research output: Contribution to journalArticle

    31 Citations (Scopus)

    Abstract

    Inulin was administered to eight volunteer patients at term gestation over a period of 3 hours before cesarean section. Inulin concentrations were repeatedly measured in maternal plasma, in fetal plasma, and in amniotic fluid at the time of delivery. Total inulin uptake of the conceptus was taken to be the sum of the inulin in the amniotic fluid and in the newborn infant. Amniotic fluid volumes were measured by ultrasound examination, and the distribution volume of inulin in the neonate was assumed to be 180 ml/kg on the basis of animal experiments. The mean permeability was 0.15 μl/(s·g) placenta. This value and the previously measured permeability for cyanocobalamin delimit a range of molecular weights from 1350 to 5200 daltons. In this range permeability to lipid-insoluble molecules is roughly proportional to the coefficients of free diffusion in water without further discrimination of molecular size by the placental barrier.

    Original languageEnglish (US)
    Pages (from-to)1165-1169
    Number of pages5
    JournalAmerican Journal of Obstetrics and Gynecology
    Volume158
    Issue number5
    StatePublished - 1988

    Fingerprint

    Inulin
    Placenta
    Permeability
    Amniotic Fluid
    Newborn Infant
    Vitamin B 12
    Cesarean Section
    Volunteers
    Molecular Weight
    Mothers
    Lipids
    Pregnancy
    Water

    ASJC Scopus subject areas

    • Medicine(all)
    • Obstetrics and Gynecology

    Cite this

    Thornburg, K., Burry, K. J., King Adams, A., Kirk, E. P., & Faber, J. J. (1988). Permeability of placenta to inulin. American Journal of Obstetrics and Gynecology, 158(5), 1165-1169.

    Permeability of placenta to inulin. / Thornburg, Kent; Burry, K. J.; King Adams, A.; Kirk, E. P.; Faber, J. J.

    In: American Journal of Obstetrics and Gynecology, Vol. 158, No. 5, 1988, p. 1165-1169.

    Research output: Contribution to journalArticle

    Thornburg, K, Burry, KJ, King Adams, A, Kirk, EP & Faber, JJ 1988, 'Permeability of placenta to inulin', American Journal of Obstetrics and Gynecology, vol. 158, no. 5, pp. 1165-1169.
    Thornburg K, Burry KJ, King Adams A, Kirk EP, Faber JJ. Permeability of placenta to inulin. American Journal of Obstetrics and Gynecology. 1988;158(5):1165-1169.
    Thornburg, Kent ; Burry, K. J. ; King Adams, A. ; Kirk, E. P. ; Faber, J. J. / Permeability of placenta to inulin. In: American Journal of Obstetrics and Gynecology. 1988 ; Vol. 158, No. 5. pp. 1165-1169.
    @article{a677368fdeaf4dae9d0a8eba030053e3,
    title = "Permeability of placenta to inulin",
    abstract = "Inulin was administered to eight volunteer patients at term gestation over a period of 3 hours before cesarean section. Inulin concentrations were repeatedly measured in maternal plasma, in fetal plasma, and in amniotic fluid at the time of delivery. Total inulin uptake of the conceptus was taken to be the sum of the inulin in the amniotic fluid and in the newborn infant. Amniotic fluid volumes were measured by ultrasound examination, and the distribution volume of inulin in the neonate was assumed to be 180 ml/kg on the basis of animal experiments. The mean permeability was 0.15 μl/(s·g) placenta. This value and the previously measured permeability for cyanocobalamin delimit a range of molecular weights from 1350 to 5200 daltons. In this range permeability to lipid-insoluble molecules is roughly proportional to the coefficients of free diffusion in water without further discrimination of molecular size by the placental barrier.",
    author = "Kent Thornburg and Burry, {K. J.} and {King Adams}, A. and Kirk, {E. P.} and Faber, {J. J.}",
    year = "1988",
    language = "English (US)",
    volume = "158",
    pages = "1165--1169",
    journal = "American Journal of Obstetrics and Gynecology",
    issn = "0002-9378",
    publisher = "Mosby Inc.",
    number = "5",

    }

    TY - JOUR

    T1 - Permeability of placenta to inulin

    AU - Thornburg, Kent

    AU - Burry, K. J.

    AU - King Adams, A.

    AU - Kirk, E. P.

    AU - Faber, J. J.

    PY - 1988

    Y1 - 1988

    N2 - Inulin was administered to eight volunteer patients at term gestation over a period of 3 hours before cesarean section. Inulin concentrations were repeatedly measured in maternal plasma, in fetal plasma, and in amniotic fluid at the time of delivery. Total inulin uptake of the conceptus was taken to be the sum of the inulin in the amniotic fluid and in the newborn infant. Amniotic fluid volumes were measured by ultrasound examination, and the distribution volume of inulin in the neonate was assumed to be 180 ml/kg on the basis of animal experiments. The mean permeability was 0.15 μl/(s·g) placenta. This value and the previously measured permeability for cyanocobalamin delimit a range of molecular weights from 1350 to 5200 daltons. In this range permeability to lipid-insoluble molecules is roughly proportional to the coefficients of free diffusion in water without further discrimination of molecular size by the placental barrier.

    AB - Inulin was administered to eight volunteer patients at term gestation over a period of 3 hours before cesarean section. Inulin concentrations were repeatedly measured in maternal plasma, in fetal plasma, and in amniotic fluid at the time of delivery. Total inulin uptake of the conceptus was taken to be the sum of the inulin in the amniotic fluid and in the newborn infant. Amniotic fluid volumes were measured by ultrasound examination, and the distribution volume of inulin in the neonate was assumed to be 180 ml/kg on the basis of animal experiments. The mean permeability was 0.15 μl/(s·g) placenta. This value and the previously measured permeability for cyanocobalamin delimit a range of molecular weights from 1350 to 5200 daltons. In this range permeability to lipid-insoluble molecules is roughly proportional to the coefficients of free diffusion in water without further discrimination of molecular size by the placental barrier.

    UR - http://www.scopus.com/inward/record.url?scp=0023883759&partnerID=8YFLogxK

    UR - http://www.scopus.com/inward/citedby.url?scp=0023883759&partnerID=8YFLogxK

    M3 - Article

    C2 - 3369499

    AN - SCOPUS:0023883759

    VL - 158

    SP - 1165

    EP - 1169

    JO - American Journal of Obstetrics and Gynecology

    JF - American Journal of Obstetrics and Gynecology

    SN - 0002-9378

    IS - 5

    ER -