Peripheral plasma immunoreactive 6-oxo-prostaglandin F(1α) and gynaecological tumours

M. Alam, M. Jogee, W. G. MacGregor, J. W. Dowdell, M. G. Elder, Leslie Myatt

Research output: Contribution to journalArticle

13 Citations (Scopus)

Abstract

Peripheral plasma levels of immunoreactive 6-oxo-PGF(1α), the stable hydrolysis product of prostacyclin, were significantly higher in female patients with tumours of the genital tract than in normal controls. In the groups with malignant tumours, these high levels declined after operation and/or radiotherapy if the tumour responded to treatment. In patients who did not respond to treatment or with tumour recurrence, levels of plasma 6-oxo-PGF(1α) remained high or even rose further. Benign gynaecological tumours were also associated with significant raised plasma 6-oxo-PGF(1α) levels, and these fell to normal levels immediately on surgical removal of the tumour. Possible reasons for these alterations are described. Further investigations are warranted to see whether serial measurements of plasma 6-oxo-PGF(1α) could be used as a prognostic index for the clinical status of patients with gynaecological tumours.

Original languageEnglish (US)
Pages (from-to)384-389
Number of pages6
JournalBritish Journal of Cancer
Volume45
Issue number3
DOIs
StatePublished - 1982
Externally publishedYes

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Prostaglandins F
Neoplasms
Epoprostenol
Hydrolysis
Radiotherapy
Recurrence
Therapeutics

ASJC Scopus subject areas

  • Cancer Research
  • Oncology

Cite this

Peripheral plasma immunoreactive 6-oxo-prostaglandin F(1α) and gynaecological tumours. / Alam, M.; Jogee, M.; MacGregor, W. G.; Dowdell, J. W.; Elder, M. G.; Myatt, Leslie.

In: British Journal of Cancer, Vol. 45, No. 3, 1982, p. 384-389.

Research output: Contribution to journalArticle

Alam, M. ; Jogee, M. ; MacGregor, W. G. ; Dowdell, J. W. ; Elder, M. G. ; Myatt, Leslie. / Peripheral plasma immunoreactive 6-oxo-prostaglandin F(1α) and gynaecological tumours. In: British Journal of Cancer. 1982 ; Vol. 45, No. 3. pp. 384-389.
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