Peripheral nerve abnormalities in aging rats

N. Grover-Johnson, Peter Spencer

Research output: Contribution to journalArticle

98 Citations (Scopus)

Abstract

The sciatic/tibial/plantar nerve complex of normal aged rats displays striking morphological changes that are most pronounced distally. Nerve fiber abnormalities include: (a) large numbers of axonal glycogenosomes, mitochondria, dense membranous bodies, and decorated particles; (b) adaxonal Schwann cell processes sequestering portions of axoplasm; (c) swollen demyelinated and remyelinated axons, some encircled by supernumerary cellular processes; and (d) collagen pockets, denervated Schwann cell columns, and empty basal laminae. Abnormalities a and b were encountered with increasing frequency on descent through the tibial and plantar nerves. Abnormalities b, c, and d were found in lateral and medial plantar nerves, where they were associated with an enlarged endoneurial space. Found in animals kept in cages with smooth or wire-mesh floors, the incidence of these changes increased with advancing age. They are attributed to trauma and ischemia from chronic pressure on the plantar nerve.

Original languageEnglish (US)
Pages (from-to)155-265
Number of pages111
JournalJournal of Neuropathology and Experimental Neurology
Volume40
Issue number2
StatePublished - 1981
Externally publishedYes

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Tibial Nerve
Peripheral Nerves
Schwann Cells
Nerve Fibers
Basement Membrane
Axons
Mitochondria
Collagen
Ischemia
Pressure
Incidence
Wounds and Injuries

ASJC Scopus subject areas

  • Clinical Neurology
  • Pathology and Forensic Medicine
  • Cellular and Molecular Neuroscience
  • Neurology
  • Neuroscience(all)

Cite this

Peripheral nerve abnormalities in aging rats. / Grover-Johnson, N.; Spencer, Peter.

In: Journal of Neuropathology and Experimental Neurology, Vol. 40, No. 2, 1981, p. 155-265.

Research output: Contribution to journalArticle

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