Peripheral leukocyte count and leukocyte indexes in healthy newborn term infants

Robert Schelonka, Bradley A. Yoder, Susan E. desJardins, Robert B. Hall, T. Jeffrey Butler

Research output: Contribution to journalArticle

62 Citations (Scopus)

Abstract

Purpose: This study was designed to determine normal values for the peripheral leukocyte count and leukocyte indexes in healthy term neonates at a specific time after birth. Methods: We prospectively enrolled 193 healthy term-gestation neonates with no identifiable perinatal risk factors for sepsis. At 4 hours of age a blood sample was collected by warmed heel stick. An automated Coulter complete blood cell count and a 100-cell manual differential leukocyte count were performed on each sample. The differential count was performed by a single hematopathologist unaware of the clinical status of each infant. Perinatal factors were identified by review of the mothers' and infants' hospital records. Results: The mean ratio of immature to total neutrophils was 0.16 (SD 0.10), and the 10% to 90% range was 0.05 to 0.27. The mean leukocyte count was 24.06 × 109/L (24,060/mm3), and the 10% to 90% range was 16.2 to 31.5 × 109/L (16,200 to 31,500/mm3). Neutropenia, 9/L (1500/mm3) segmented plus band form neutrophils, was not observed. Of all the perinatal factors studied, only the duration of stage 1 labor was found to be associated with significant elevations in the leukocyte and absolute neutrophil counts. Conclusions: Previously published normal ranges for leukocyte indexes in healthy newborn infants during the early neonatal period are too restrictive; reference standards should be broadened. (J PEDIATR 1994;125:603-6).

Original languageEnglish (US)
Pages (from-to)603-606
Number of pages4
JournalThe Journal of Pediatrics
Volume125
Issue number4
DOIs
StatePublished - 1994
Externally publishedYes

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Leukocyte Count
Neutrophils
Leukocytes
Blood Cell Count
Newborn Infant
Reference Values
Heel
Hospital Records
Neutropenia
Sepsis
Mothers
Parturition
Pregnancy

ASJC Scopus subject areas

  • Pediatrics, Perinatology, and Child Health

Cite this

Peripheral leukocyte count and leukocyte indexes in healthy newborn term infants. / Schelonka, Robert; Yoder, Bradley A.; desJardins, Susan E.; Hall, Robert B.; Butler, T. Jeffrey.

In: The Journal of Pediatrics, Vol. 125, No. 4, 1994, p. 603-606.

Research output: Contribution to journalArticle

Schelonka, Robert ; Yoder, Bradley A. ; desJardins, Susan E. ; Hall, Robert B. ; Butler, T. Jeffrey. / Peripheral leukocyte count and leukocyte indexes in healthy newborn term infants. In: The Journal of Pediatrics. 1994 ; Vol. 125, No. 4. pp. 603-606.
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