Peripheral biomarkers of stroke: Focus on circulatory microRNAs

Murali Vijayan, P. Hemachandra Reddy

    Research output: Contribution to journalReview articlepeer-review

    51 Scopus citations

    Abstract

    Stroke is the second leading cause of death in the world. Stroke occurs when blood flow stops, and that stoppage results in reduced oxygen supply to neurons in the brain. The occurrence of stroke increases with age, but anyone at any age can suffer from stroke. Recent research has implicated multiple cellular changes in stroke patients, including oxidative stress and mitochondrial dysfunction, inflammatory responses, and changes in mRNA and proteins. Recent research has also revealed that stroke is associated with modifiable and non-modifiable risk factors. Stroke can be controlled by modifiable risk factors, including diet, cardiovascular, hypertension, smoking, diabetes, obesity, metabolic syndrome, depression and traumatic brain injury. Stroke is the major risk factor for vascular dementia (VaD) and Alzheimer's disease (AD). The purpose of this article is to review the latest developments in research efforts directed at identifying 1) latest developments in identifying biomarkers in peripheral and central nervous system tissues, 2) changes in microRNAs (miRNAs) in patients with stroke, 3) miRNA profile and function in animal brain, and 4) protein biomarkers in ischemic stroke. This article also reviews research investigating circulatory miRNAs as peripheral biomarkers of stroke.

    Original languageEnglish (US)
    Pages (from-to)1984-1993
    Number of pages10
    JournalBiochimica et Biophysica Acta - Molecular Basis of Disease
    Volume1862
    Issue number10
    DOIs
    StatePublished - Oct 1 2016

    Keywords

    • Alzheimer's disease
    • Circulatory microRNA
    • Plasma
    • Protein biomarker
    • Serum
    • Stroke
    • Vascular dementia

    ASJC Scopus subject areas

    • Molecular Medicine
    • Molecular Biology

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