TY - JOUR
T1 - Perioperative oxygen supplementation and surgical site infection after cesarean delivery
T2 - A randomized trial
AU - Duggal, Neena
AU - Poddatorri, Vineela
AU - Noroozkhani, Sara
AU - Siddik-Ahmad, R. Iram
AU - Caughey, Aaron B.
PY - 2013/7
Y1 - 2013/7
N2 - OBJECTIVE:: To evaluate whether supplemental perioperative oxygen decreases surgical site wound infections or endometritis. STUDY DESIGN:: This was a prospective, randomized trial. Patients who were to undergo cesarean delivery were recruited and randomly allocated to either 30% or 80% oxygen during the cesarean delivery and for 1 hour after surgery. The obstetricians and patients were blinded to the concentration of oxygen used. Patients were evaluated for wound infection or endometritis during their hospital stay and by 6 weeks postpartum. The primary end point was a composite of either surgical site infection or endometritis. RESULTS:: Eight hundred thirty-one patients were recruited. Of these, 415 participants received 30% oxygen perioperatively and 416 received 80% oxygen. The groups were well matched for age, race, parity, diabetes, number of previous cesarean deliveries, and scheduled compared with unscheduled cesarean deliveries. An intention-to-treat analysis was used. There was no difference in the primary composite outcome (8.2% in women who received 30% oxygen compared with 8.2% in women who received 80% oxygen, P=.89), no difference in surgical site infection in the two groups (5.5% compared with 5.8%, P=.98), and no significant difference in endometritis in the two groups (2.7% compared with 2.4%, P=.66), respectively. CONCLUSION:: Women who received 80% supplemental oxygen perioperatively did not have a lower rate of a surgical site infection or endometritis as compared with women who received 30% supplemental oxygen concentration.
AB - OBJECTIVE:: To evaluate whether supplemental perioperative oxygen decreases surgical site wound infections or endometritis. STUDY DESIGN:: This was a prospective, randomized trial. Patients who were to undergo cesarean delivery were recruited and randomly allocated to either 30% or 80% oxygen during the cesarean delivery and for 1 hour after surgery. The obstetricians and patients were blinded to the concentration of oxygen used. Patients were evaluated for wound infection or endometritis during their hospital stay and by 6 weeks postpartum. The primary end point was a composite of either surgical site infection or endometritis. RESULTS:: Eight hundred thirty-one patients were recruited. Of these, 415 participants received 30% oxygen perioperatively and 416 received 80% oxygen. The groups were well matched for age, race, parity, diabetes, number of previous cesarean deliveries, and scheduled compared with unscheduled cesarean deliveries. An intention-to-treat analysis was used. There was no difference in the primary composite outcome (8.2% in women who received 30% oxygen compared with 8.2% in women who received 80% oxygen, P=.89), no difference in surgical site infection in the two groups (5.5% compared with 5.8%, P=.98), and no significant difference in endometritis in the two groups (2.7% compared with 2.4%, P=.66), respectively. CONCLUSION:: Women who received 80% supplemental oxygen perioperatively did not have a lower rate of a surgical site infection or endometritis as compared with women who received 30% supplemental oxygen concentration.
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U2 - 10.1097/AOG.0b013e318297ec6c
DO - 10.1097/AOG.0b013e318297ec6c
M3 - Article
C2 - 23743467
AN - SCOPUS:84880571389
SN - 0029-7844
VL - 122
SP - 79
EP - 84
JO - Obstetrics and gynecology
JF - Obstetrics and gynecology
IS - 1
ER -