Perioperative administration of gabapentin for shoulder arthroscopy

A prospective, randomized, double-blind, placebo-controlled study

Dennis Spence, Jason Goff, Erin Mohan, Kirsten Bowen, Lisa Osborne Smith, John Maye

Research output: Contribution to journalArticle

7 Citations (Scopus)

Abstract

Recent studies suggest gabapentin has opioid-sparing effects and may reduce acute postoperative pain. However, there is limited research on the efficacy of gabapentin when combined in a multimodal approach after shoulder arthroscopy under general anesthesia with an interscalene block. We conducted prospective, double-blind study of 70 patients who were randomized to receive either 300 mg of gabapentin or placebo 1 hour before surgery, then twice a day for 2 days. The primary outcome was average pain scores. Secondary outcomes included differences in morphine equivalents, adverse effects, and sleep patterns. No significant differences in pain scores were found on day 1 (gabapentin mean [SD], 4.23 [2.61], vs placebo, 4.61 [2.57]; P = .58) or day 2 (gabapentin, 4.26 [2.39], vs placebo, 4.03 [2.34]; P = .71). Total morphine equivalents on day 1 (gabapentin, 9.75 mg [6.58 mg], vs placebo, 9.52 mg [4.75 mg]; P = .88) and day 2 (gabapentin, 9.21 mg [6.66 mg], vs placebo, 6.93 mg [5.44 mg]; P = .17) were similar. Adverse effects and sleep patterns were similar (P > .05). These results suggest this dosing regimen of gabapentin is not efficacious in improving outcomes in patients undergoing shoulder arthroscopy under general anesthesia with an interscalene block.

Original languageEnglish (US)
JournalAANA Journal
Volume79
Issue numberSUPPL. 4
StatePublished - Aug 1 2011
Externally publishedYes

Fingerprint

Arthroscopy
Placebos
General Anesthesia
Morphine
Sleep
Pain
gabapentin
Acute Pain
Postoperative Pain
Double-Blind Method
Opioid Analgesics
Research

Keywords

  • Central sensitization
  • Gabapentin
  • Interscalene block
  • Postoperative pain
  • Shoulder arthroscopy.

ASJC Scopus subject areas

  • Anesthesiology and Pain Medicine
  • Medical–Surgical
  • Advanced and Specialized Nursing

Cite this

Perioperative administration of gabapentin for shoulder arthroscopy : A prospective, randomized, double-blind, placebo-controlled study. / Spence, Dennis; Goff, Jason; Mohan, Erin; Bowen, Kirsten; Osborne Smith, Lisa; Maye, John.

In: AANA Journal, Vol. 79, No. SUPPL. 4, 01.08.2011.

Research output: Contribution to journalArticle

Spence, Dennis ; Goff, Jason ; Mohan, Erin ; Bowen, Kirsten ; Osborne Smith, Lisa ; Maye, John. / Perioperative administration of gabapentin for shoulder arthroscopy : A prospective, randomized, double-blind, placebo-controlled study. In: AANA Journal. 2011 ; Vol. 79, No. SUPPL. 4.
@article{e56ef17b551749588c575b80492a3aec,
title = "Perioperative administration of gabapentin for shoulder arthroscopy: A prospective, randomized, double-blind, placebo-controlled study",
abstract = "Recent studies suggest gabapentin has opioid-sparing effects and may reduce acute postoperative pain. However, there is limited research on the efficacy of gabapentin when combined in a multimodal approach after shoulder arthroscopy under general anesthesia with an interscalene block. We conducted prospective, double-blind study of 70 patients who were randomized to receive either 300 mg of gabapentin or placebo 1 hour before surgery, then twice a day for 2 days. The primary outcome was average pain scores. Secondary outcomes included differences in morphine equivalents, adverse effects, and sleep patterns. No significant differences in pain scores were found on day 1 (gabapentin mean [SD], 4.23 [2.61], vs placebo, 4.61 [2.57]; P = .58) or day 2 (gabapentin, 4.26 [2.39], vs placebo, 4.03 [2.34]; P = .71). Total morphine equivalents on day 1 (gabapentin, 9.75 mg [6.58 mg], vs placebo, 9.52 mg [4.75 mg]; P = .88) and day 2 (gabapentin, 9.21 mg [6.66 mg], vs placebo, 6.93 mg [5.44 mg]; P = .17) were similar. Adverse effects and sleep patterns were similar (P > .05). These results suggest this dosing regimen of gabapentin is not efficacious in improving outcomes in patients undergoing shoulder arthroscopy under general anesthesia with an interscalene block.",
keywords = "Central sensitization, Gabapentin, Interscalene block, Postoperative pain, Shoulder arthroscopy.",
author = "Dennis Spence and Jason Goff and Erin Mohan and Kirsten Bowen and {Osborne Smith}, Lisa and John Maye",
year = "2011",
month = "8",
day = "1",
language = "English (US)",
volume = "79",
journal = "AANA Journal",
issn = "0094-6354",
publisher = "AANA Publishing Inc.",
number = "SUPPL. 4",

}

TY - JOUR

T1 - Perioperative administration of gabapentin for shoulder arthroscopy

T2 - A prospective, randomized, double-blind, placebo-controlled study

AU - Spence, Dennis

AU - Goff, Jason

AU - Mohan, Erin

AU - Bowen, Kirsten

AU - Osborne Smith, Lisa

AU - Maye, John

PY - 2011/8/1

Y1 - 2011/8/1

N2 - Recent studies suggest gabapentin has opioid-sparing effects and may reduce acute postoperative pain. However, there is limited research on the efficacy of gabapentin when combined in a multimodal approach after shoulder arthroscopy under general anesthesia with an interscalene block. We conducted prospective, double-blind study of 70 patients who were randomized to receive either 300 mg of gabapentin or placebo 1 hour before surgery, then twice a day for 2 days. The primary outcome was average pain scores. Secondary outcomes included differences in morphine equivalents, adverse effects, and sleep patterns. No significant differences in pain scores were found on day 1 (gabapentin mean [SD], 4.23 [2.61], vs placebo, 4.61 [2.57]; P = .58) or day 2 (gabapentin, 4.26 [2.39], vs placebo, 4.03 [2.34]; P = .71). Total morphine equivalents on day 1 (gabapentin, 9.75 mg [6.58 mg], vs placebo, 9.52 mg [4.75 mg]; P = .88) and day 2 (gabapentin, 9.21 mg [6.66 mg], vs placebo, 6.93 mg [5.44 mg]; P = .17) were similar. Adverse effects and sleep patterns were similar (P > .05). These results suggest this dosing regimen of gabapentin is not efficacious in improving outcomes in patients undergoing shoulder arthroscopy under general anesthesia with an interscalene block.

AB - Recent studies suggest gabapentin has opioid-sparing effects and may reduce acute postoperative pain. However, there is limited research on the efficacy of gabapentin when combined in a multimodal approach after shoulder arthroscopy under general anesthesia with an interscalene block. We conducted prospective, double-blind study of 70 patients who were randomized to receive either 300 mg of gabapentin or placebo 1 hour before surgery, then twice a day for 2 days. The primary outcome was average pain scores. Secondary outcomes included differences in morphine equivalents, adverse effects, and sleep patterns. No significant differences in pain scores were found on day 1 (gabapentin mean [SD], 4.23 [2.61], vs placebo, 4.61 [2.57]; P = .58) or day 2 (gabapentin, 4.26 [2.39], vs placebo, 4.03 [2.34]; P = .71). Total morphine equivalents on day 1 (gabapentin, 9.75 mg [6.58 mg], vs placebo, 9.52 mg [4.75 mg]; P = .88) and day 2 (gabapentin, 9.21 mg [6.66 mg], vs placebo, 6.93 mg [5.44 mg]; P = .17) were similar. Adverse effects and sleep patterns were similar (P > .05). These results suggest this dosing regimen of gabapentin is not efficacious in improving outcomes in patients undergoing shoulder arthroscopy under general anesthesia with an interscalene block.

KW - Central sensitization

KW - Gabapentin

KW - Interscalene block

KW - Postoperative pain

KW - Shoulder arthroscopy.

UR - http://www.scopus.com/inward/record.url?scp=84860410436&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=84860410436&partnerID=8YFLogxK

M3 - Article

VL - 79

JO - AANA Journal

JF - AANA Journal

SN - 0094-6354

IS - SUPPL. 4

ER -