Perioperative administration of gabapentin for shoulder arthroscopy: A prospective, randomized, double-blind, placebo-controlled study

Dennis Spence, Jason Goff, Erin Mohan, Kirsten Bowen, Lisa Osborne Smith, John Maye

Research output: Contribution to journalArticle

8 Scopus citations


Recent studies suggest gabapentin has opioid-sparing effects and may reduce acute postoperative pain. However, there is limited research on the efficacy of gabapentin when combined in a multimodal approach after shoulder arthroscopy under general anesthesia with an interscalene block. We conducted prospective, double-blind study of 70 patients who were randomized to receive either 300 mg of gabapentin or placebo 1 hour before surgery, then twice a day for 2 days. The primary outcome was average pain scores. Secondary outcomes included differences in morphine equivalents, adverse effects, and sleep patterns. No significant differences in pain scores were found on day 1 (gabapentin mean [SD], 4.23 [2.61], vs placebo, 4.61 [2.57]; P = .58) or day 2 (gabapentin, 4.26 [2.39], vs placebo, 4.03 [2.34]; P = .71). Total morphine equivalents on day 1 (gabapentin, 9.75 mg [6.58 mg], vs placebo, 9.52 mg [4.75 mg]; P = .88) and day 2 (gabapentin, 9.21 mg [6.66 mg], vs placebo, 6.93 mg [5.44 mg]; P = .17) were similar. Adverse effects and sleep patterns were similar (P > .05). These results suggest this dosing regimen of gabapentin is not efficacious in improving outcomes in patients undergoing shoulder arthroscopy under general anesthesia with an interscalene block.

Original languageEnglish (US)
JournalAANA Journal
Issue numberSUPPL. 4
Publication statusPublished - Aug 1 2011
Externally publishedYes



  • Central sensitization
  • Gabapentin
  • Interscalene block
  • Postoperative pain
  • Shoulder arthroscopy.

ASJC Scopus subject areas

  • Anesthesiology and Pain Medicine
  • Medical–Surgical
  • Advanced and Specialized Nursing

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