Perineural spread of cancer to the skull base

E. Hanna, Jane Weissman, S. Kapadia, R. Carrau, C. Snvderman, I. Janecka

Research output: Contribution to journalArticle

Abstract

Perineural spread, is a well recognized but poorly understand phenomenon that has been described in mucosal and cutaneous cancer of the head and neck. Perineural spread can be a portal of entry for head and neck cancer to the central nervous system. This usually occurs through the foramina at the cranial base. Failure to detect perineural involvement prior to treatment can have significant consequences on the outcome of oncologic therapy. High resolution imaging including CT and MRI is important in this respect, although an optimum modality with a high degree of sensitivity and specificity is still lacking. This study evaluates the sensitivity and specificity of CT and MRI in detecting perineural spread in head and neck cancer/skull base tumors. The surgical specimens of 26 patients were thoroughly examined by one pathologist for the presence of perineural spread in large named nerves. A total of 37 nerves were examined and perineural spread was detected in 24 (65%). The pre-operative imaging studies (CT/MRI) were then reviewed retrospectively by one head and neck radiologist who was unaware of the pathology report. Radiological evidence of perineural spread was considered to be present if there was widening of bony foramina on CT and/or enhancement of named nerves on MRJ. The sensitivity and specificity of CT scans in detecting perineural spread is 87% and 89% respectively. MRI had a higher sensitivity ( 100%) and specificity (92%).

Original languageEnglish (US)
Pages (from-to)32
Number of pages1
JournalSkull Base Surgery
Volume7
Issue numberSUPPL. 1
StatePublished - 1997
Externally publishedYes

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Skull Base
Head and Neck Neoplasms
Sensitivity and Specificity
Neoplasms
Skin Neoplasms
Neck
Central Nervous System
Head
Pathology
Therapeutics

ASJC Scopus subject areas

  • Clinical Neurology

Cite this

Hanna, E., Weissman, J., Kapadia, S., Carrau, R., Snvderman, C., & Janecka, I. (1997). Perineural spread of cancer to the skull base. Skull Base Surgery, 7(SUPPL. 1), 32.

Perineural spread of cancer to the skull base. / Hanna, E.; Weissman, Jane; Kapadia, S.; Carrau, R.; Snvderman, C.; Janecka, I.

In: Skull Base Surgery, Vol. 7, No. SUPPL. 1, 1997, p. 32.

Research output: Contribution to journalArticle

Hanna, E, Weissman, J, Kapadia, S, Carrau, R, Snvderman, C & Janecka, I 1997, 'Perineural spread of cancer to the skull base', Skull Base Surgery, vol. 7, no. SUPPL. 1, pp. 32.
Hanna E, Weissman J, Kapadia S, Carrau R, Snvderman C, Janecka I. Perineural spread of cancer to the skull base. Skull Base Surgery. 1997;7(SUPPL. 1):32.
Hanna, E. ; Weissman, Jane ; Kapadia, S. ; Carrau, R. ; Snvderman, C. ; Janecka, I. / Perineural spread of cancer to the skull base. In: Skull Base Surgery. 1997 ; Vol. 7, No. SUPPL. 1. pp. 32.
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