Perinatal transmission of SHIV-SF162P3 in Macaca nemestrina

Pushpa Jayaraman, Deepika Mohan, Patricia Polacino, LaRene Kuller, Nadeem Sheikh, Helle Bielefeldt-Ohmann, Barbra Richardson, David Anderson, Shiu Lok Hu, Nancy Haigwood

Research output: Contribution to journalArticle

14 Scopus citations

Abstract

We developed a SHIV/macaque model of transmission from infected dams to their infants. Ten pregnant dams were infected intravenously with 100 MID50 of macaque-titered SHIV-SF162P3 during the second trimester. Nine infants were born; the seven surviving beyond day of birth suckled for 6 months. Four of nine infants were infected (transmission rate = 44.4%), with one infection in utero, and three intrapartum and/or immediately post-birth via suckling. Varying levels of binding and neutralizing antibodies were transplacentally transferred to infants. Passive antibodies were detected in plasma on the day of birth and persisted for 5 weeks. Infants infected at or after birth controlled acute and post-acute viremia. Exposure to maternal SHIV-SF162P3 during birth and suckling in the presence of autologous maternal neutralizing antibodies may have affected transmission or pathogenesis in the infants. This transmission model can allow investigation of key parameters involved in perinatal transmission of HIV.

Original languageEnglish (US)
Pages (from-to)243-250
Number of pages8
JournalJournal of Medical Primatology
Volume33
Issue number5-6
DOIs
Publication statusPublished - Oct 2004
Externally publishedYes

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Keywords

  • Maternal transmission
  • Neutralizing antibody
  • Primate model
  • SHIV-SF162P3

ASJC Scopus subject areas

  • Animal Science and Zoology
  • veterinary(all)

Cite this

Jayaraman, P., Mohan, D., Polacino, P., Kuller, L., Sheikh, N., Bielefeldt-Ohmann, H., ... Haigwood, N. (2004). Perinatal transmission of SHIV-SF162P3 in Macaca nemestrina. Journal of Medical Primatology, 33(5-6), 243-250. https://doi.org/10.1111/j.1600-0684.2004.00079.x