Perinatal transmission of SHIV-SF162P3 in Macaca nemestrina

Pushpa Jayaraman, Deepika Mohan, Patricia Polacino, La Rene Kuller, Nadeem Sheikh, Helle Bielefeldt-Ohmann, Barbra Richardson, David Anderson, Shiu Lok Hu, Nancy L. Haigwood

    Research output: Contribution to journalArticle

    14 Scopus citations

    Abstract

    We developed a SHIV/macaque model of transmission from infected dams to their infants. Ten pregnant dams were infected intravenously with 100 MID50 of macaque-titered SHIV-SF162P3 during the second trimester. Nine infants were born; the seven surviving beyond day of birth suckled for 6 months. Four of nine infants were infected (transmission rate = 44.4%), with one infection in utero, and three intrapartum and/or immediately post-birth via suckling. Varying levels of binding and neutralizing antibodies were transplacentally transferred to infants. Passive antibodies were detected in plasma on the day of birth and persisted for 5 weeks. Infants infected at or after birth controlled acute and post-acute viremia. Exposure to maternal SHIV-SF162P3 during birth and suckling in the presence of autologous maternal neutralizing antibodies may have affected transmission or pathogenesis in the infants. This transmission model can allow investigation of key parameters involved in perinatal transmission of HIV.

    Original languageEnglish (US)
    Pages (from-to)243-250
    Number of pages8
    JournalJournal of medical primatology
    Volume33
    Issue number5-6
    DOIs
    StatePublished - Oct 1 2004

    Keywords

    • Maternal transmission
    • Neutralizing antibody
    • Primate model
    • SHIV-SF162P3

    ASJC Scopus subject areas

    • Animal Science and Zoology
    • veterinary(all)

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    Jayaraman, P., Mohan, D., Polacino, P., Kuller, L. R., Sheikh, N., Bielefeldt-Ohmann, H., Richardson, B., Anderson, D., Hu, S. L., & Haigwood, N. L. (2004). Perinatal transmission of SHIV-SF162P3 in Macaca nemestrina. Journal of medical primatology, 33(5-6), 243-250. https://doi.org/10.1111/j.1600-0684.2004.00079.x