Perinatal Nutrition and Programmed Risk for Neuropsychiatric Disorders

A Focus on Animal Models

Madison DeCapo, Jacqueline R. Thompson, Geoffrey Dunn, Elinor Sullivan

    Research output: Contribution to journalArticle

    2 Citations (Scopus)

    Abstract

    Maternal nutrition is critically important for fetal development. Recent human studies demonstrate a strong connection between diet during pregnancy and offspring risk for neuropsychiatric disorders including depression, anxiety, and attention-deficit/hyperactivity disorder. Animal models have emerged as a crucial tool for understanding maternal nutrition's contribution to prenatal programming and the later development of neuropsychiatric disorders. This review highlights preclinical studies examining how maternal consumption of the three macronutrients (protein, fats, and carbohydrates) influence offspring negative-valence behaviors relevant to neuropsychiatric disorders. We highlight the translational aspects of animal models and so examine exposure periods that mirror the neurodevelopmental stages of human gestation. Because of our emphasis on programmed changes in neurobehavioral development, studies that continue diet exposure until assessment in adulthood are not discussed. The presented research provides a strong foundation of preclinical evidence of nutritional programming of neurobehavioral impairments. Alterations in risk assessment and response were observed alongside neurodevelopmental impairments related to neurogenesis, synaptogenesis, and synaptic plasticity. To date, the large majority of studies utilized rodent models, and the field could benefit from additional study of large-animal models. Additional future directions are discussed, including the need for further studies examining how sex as a biological variable affects the contribution of maternal nutrition to prenatal programming.

    Original languageEnglish (US)
    JournalBiological Psychiatry
    DOIs
    StateAccepted/In press - Jan 1 2018

    Fingerprint

    Animal Models
    Embryonic and Fetal Development
    Mothers
    Diet
    Pregnancy
    Neuronal Plasticity
    Neurogenesis
    Attention Deficit Disorder with Hyperactivity
    Fetal Development
    Rodentia
    Anxiety
    Fats
    Carbohydrates
    Depression
    Research
    Proteins

    Keywords

    • Animal model
    • Behavior
    • Maternal diet
    • Neuropsychiatric disorders
    • Nutrition
    • Prenatal programming

    ASJC Scopus subject areas

    • Biological Psychiatry

    Cite this

    Perinatal Nutrition and Programmed Risk for Neuropsychiatric Disorders : A Focus on Animal Models. / DeCapo, Madison; Thompson, Jacqueline R.; Dunn, Geoffrey; Sullivan, Elinor.

    In: Biological Psychiatry, 01.01.2018.

    Research output: Contribution to journalArticle

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