Perinatal aromatase activity in male and female rats

Effect of prenatal alcohol exposure

R. F. McGivern, Charles Roselli, R. J. Handa

Research output: Contribution to journalArticle

18 Citations (Scopus)

Abstract

Fetal alcohol exposure has been shown to produce long-term feminizing and demasculinizing effects on male rat behaviors which are organizationally dependent upon perinatal androgen levels. Such exposure has previously been shown to suppress the normal surge of testosterone during the critical prenatal period. Since defeminization of male rate behavior is dependent upon estrogen derived from the aromatization of testosterone in brain, brain aromatase activity was measured during the perinatal period in males and females exposed to alcohol beginning on Day 14 of gestation. Aromatase activity was measured in whole hypothalamus of fetuses from Day 16 through 20 of gestation and in the hypothalamic preoptic area and amygdala of animals 6-12 hr postparturition. Hypothalamic aromatase activity was elevated in fetal alcohol exposed males compared to controls on Days 18 and 19 of gestation and on postnatal Day 1. No effect of prenatal alcohol exposure was found in females. A sex effect in aromatase activity in the amygdala was evident on Day 1 when activity was found to be greater in males than females. Overall, these findings indicate that fetal alcohol exposure will elevate regional brain aromatase activity in males, but not females during the perinatal period of neurobehavioral sexual differentiation.

Original languageEnglish (US)
Pages (from-to)769-772
Number of pages4
JournalAlcoholism: Clinical and Experimental Research
Volume12
Issue number6
StatePublished - 1988

Fingerprint

Aromatase
Rats
Alcohols
Brain
Testosterone
Amygdala
Pregnancy
Aromatization
Sex Differentiation
Preoptic Area
Androgens
Estrogens
Animals
Hypothalamus
Fetus

ASJC Scopus subject areas

  • Medicine (miscellaneous)
  • Toxicology

Cite this

Perinatal aromatase activity in male and female rats : Effect of prenatal alcohol exposure. / McGivern, R. F.; Roselli, Charles; Handa, R. J.

In: Alcoholism: Clinical and Experimental Research, Vol. 12, No. 6, 1988, p. 769-772.

Research output: Contribution to journalArticle

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