Performance of diagnostic mammography for women with signs or symptoms of breast cancer

William E. Barlow, Constance D. Lehman, Yingye Zheng, Rachel Ballard-Barbash, Bonnie C. Yankaskas, Gary R. Cutter, Patricia (Patty) Carney, Berta M. Geller, Robert Rosenberg, Karla Kerlikowske, Donald L. Weaver, Stephen H. Taplin

Research output: Contribution to journalArticle

104 Citations (Scopus)

Abstract

Background: The performance of diagnostic mammography for women with signs or symptoms of breast cancer has not been well studied. We evaluated whether age, breast density, self-reported breast lump, and previous mammography influence the performance of diagnostic mammography. Methods: From January 1996 through March 1998, prospective diagnostic mammography data from women aged 25-89 years with no previous breast cancer were linked to cancer outcomes data in six mammography registries participating in the Breast Cancer Surveillance Consortium. We used the final mammographic assessment at the end of the imaging work-up to determine abnormal mammographic examination rate, positive predictive value (PPV), sensitivity, specificity, and area under the receiver operating characteristic (ROC) curve. We used age, breast density, prior mammogram, and self-reported breast lump jointly as predictors of performance. All statistical tests were two-sided. Results: Of 41 427 diagnostic mammograms, 6279 (15.2%) were judged abnormal. The overall PPV was 21.8%, sensitivity was 85.8%, and specificity was 87.7%. Multivariate analysis showed that sensitivity and specificity generally declined as breast density increased (P = .007 and P

Original languageEnglish (US)
Pages (from-to)1151-1159
Number of pages9
JournalJournal of the National Cancer Institute
Volume94
Issue number15
StatePublished - Aug 7 2002
Externally publishedYes

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Mammography
Signs and Symptoms
Breast Neoplasms
Breast
Sensitivity and Specificity
ROC Curve
Registries
Multivariate Analysis
Breast Density
Neoplasms

ASJC Scopus subject areas

  • Cancer Research
  • Oncology

Cite this

Barlow, W. E., Lehman, C. D., Zheng, Y., Ballard-Barbash, R., Yankaskas, B. C., Cutter, G. R., ... Taplin, S. H. (2002). Performance of diagnostic mammography for women with signs or symptoms of breast cancer. Journal of the National Cancer Institute, 94(15), 1151-1159.

Performance of diagnostic mammography for women with signs or symptoms of breast cancer. / Barlow, William E.; Lehman, Constance D.; Zheng, Yingye; Ballard-Barbash, Rachel; Yankaskas, Bonnie C.; Cutter, Gary R.; Carney, Patricia (Patty); Geller, Berta M.; Rosenberg, Robert; Kerlikowske, Karla; Weaver, Donald L.; Taplin, Stephen H.

In: Journal of the National Cancer Institute, Vol. 94, No. 15, 07.08.2002, p. 1151-1159.

Research output: Contribution to journalArticle

Barlow, WE, Lehman, CD, Zheng, Y, Ballard-Barbash, R, Yankaskas, BC, Cutter, GR, Carney, PP, Geller, BM, Rosenberg, R, Kerlikowske, K, Weaver, DL & Taplin, SH 2002, 'Performance of diagnostic mammography for women with signs or symptoms of breast cancer', Journal of the National Cancer Institute, vol. 94, no. 15, pp. 1151-1159.
Barlow WE, Lehman CD, Zheng Y, Ballard-Barbash R, Yankaskas BC, Cutter GR et al. Performance of diagnostic mammography for women with signs or symptoms of breast cancer. Journal of the National Cancer Institute. 2002 Aug 7;94(15):1151-1159.
Barlow, William E. ; Lehman, Constance D. ; Zheng, Yingye ; Ballard-Barbash, Rachel ; Yankaskas, Bonnie C. ; Cutter, Gary R. ; Carney, Patricia (Patty) ; Geller, Berta M. ; Rosenberg, Robert ; Kerlikowske, Karla ; Weaver, Donald L. ; Taplin, Stephen H. / Performance of diagnostic mammography for women with signs or symptoms of breast cancer. In: Journal of the National Cancer Institute. 2002 ; Vol. 94, No. 15. pp. 1151-1159.
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