Percutaneous transcatheter one-step mechanical aortic disc valve prosthesis implantation: A preliminary feasibility study in swine

Jan Šochman, Jan H. Peregrin, Miloslav Roček, Hans A. Timmermans, Dusan Pavcnik, Josef Rösch

Research output: Contribution to journalArticle

15 Scopus citations

Abstract

Purpose: To evaluate the feasibility of one-step implantation of a new type of stent-based mechanical aortic disc valve prosthesis (MADVP) above and across the native aortic valve and its short-term function in swine with both functional and dysfunctional native valves. Methods: The MADVP consisted of a folding disc valve made of silicone elastomer attached to either a nitinol Z-stent (Z model) or a nitinol cross-braided stent (SX model). Implantation of 10 MADVPs (6 Z and 4 SX models) was attempted in 10 swine: 4 (2 Z and 2 SX models) with a functional native valve and 6 (4 Z and 2 SX models) with aortic regurgitation induced either by intentional valve injury or by MADVP placement across the native valve. MADVP function was observed for up to 3 hr after implantation. Results: MADVP implantation was successful in 9 swine. One animal died of induced massive regurgitation prior to implantation. Four MADVPs implanted above functioning native valves exhibited good function. In 5 swine with regurgitation, MADVP implantation corrected the induced native valve dysfunction and the device's continuous good function was observed in 4 animals. One MADVP (SX model) placed across native valve gradually migrated into the left ventricle. Conclusion: The tested MADVP can be implanted above and across the native valve in a one-step procedure and can replace the function of the regurgitating native valve. Further technical development and testing are warranted, preferably with a manufactured MADVP.

Original languageEnglish (US)
Pages (from-to)114-119
Number of pages6
JournalCardiovascular and interventional radiology
Volume29
Issue number1
DOIs
StatePublished - Feb 1 2006

Keywords

  • Aortic
  • Catheter-based techniques
  • Experimental work
  • Mechanical disc valve prosthesis
  • Valve regurgitation

ASJC Scopus subject areas

  • Radiology Nuclear Medicine and imaging
  • Cardiology and Cardiovascular Medicine

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