Percutaneous retroperitoneal splenorenal shunt: An experimental study in swine

Toshio Kaminou, Josef Rösch, Ryusaku Yamada, Barry T. Uchida, Dusan Pavcnik, Hans A. Timmermans, Shoji Sakaguchi, Frederick S. Keller

Research output: Contribution to journalArticle

12 Scopus citations

Abstract

PURPOSE: To evaluate the technical possibility of creating a percutaneous retroperitoneal splenorenal shunt (PRESS) in swine as a minimally invasive treatment of portal hypertension. MATERIALS AND METHODS: Five normal domestic swine underwent creation of a PRESS. A modified transjugular intrahepatic portosystemic shunt puncture set was introduced from the right femoral vein into the left renal vein. The proximal splenic vein was punctured transvenously through the retropentoneal cavity. Noncovered metallic stents were then placed to connect both veins. The animals were sacrificed 1 hour after the procedure, after follow-up splenic venography and necropsy were performed. RESULTS: Puncture of the splenic vein and stent placement were successfully completed in all cases. In four of five cases, the splenic venogram revealed good flow from the splenic vein to the left renal vein through the shunt track 1 hour after creation of the PRESS, and there was no evidence of leakage. No changes in vital signs were noticed. At necropsy, a small retroperitoneal hematoma along the stent and minimal intraperitoneal bleeding were observed. The stents were found in the retroperitoneal cavity connecting both veins in all animals. CONCLUSION: Creation of a PRESs is technically possible, and further experimental studies of its efficacy are warranted.

Original languageEnglish (US)
Pages (from-to)799-802
Number of pages4
JournalRADIOLOGY
Volume206
Issue number3
DOIs
StatePublished - Mar 1998

Keywords

  • Hypertension, portal
  • Interventional procedures, experimental
  • Shunts, splenorenal
  • Stents and protheses

ASJC Scopus subject areas

  • Radiology Nuclear Medicine and imaging

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    Kaminou, T., Rösch, J., Yamada, R., Uchida, B. T., Pavcnik, D., Timmermans, H. A., Sakaguchi, S., & Keller, F. S. (1998). Percutaneous retroperitoneal splenorenal shunt: An experimental study in swine. RADIOLOGY, 206(3), 799-802. https://doi.org/10.1148/radiology.206.3.9494504