Percutaneous bioprosthetic venous valve: A long-term study in sheep

Dusan Pavcnik, Barry Uchida, Hans A. Timmermans, Christopher Corless, Michael O'Hara, Naoyuki Toyota, Gregory (Greg) Moneta, Frederick Keller, Josef Rosch

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Abstract

A long-term evaluation of a new percutaneously placed bioprosthetic, bicuspid venous valve (BVV) consisting of a square stent and small intestinal submucosa (SIS) covering was performed in 12 sheep. Of 26 BVVs placed into the jugular veins, 25 exhibited good valve function on immediate venography and 22 on venograms obtained before the sheep were killed. Gross and histologic examination results demonstrated incorporation of remodeled and endothelialized SIS BVVs into the vein wall. Slight to moderate leaflet thickening was found mostly at their bases. Percutaneously placed SIS BVV is a promising one-way, competent valve that resists venous back-pressure while allowing forward flow.

Original languageEnglish (US)
Pages (from-to)598-602
Number of pages5
JournalJournal of Vascular Surgery
Volume35
Issue number3
DOIs
Publication statusPublished - Mar 2002

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ASJC Scopus subject areas

  • Cardiology and Cardiovascular Medicine
  • Surgery

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