Perceived risk following melanoma genetic testing: A 2-year prospective study distinguishing subjective estimates from recall

Lisa G. Aspinwall, Jennifer M. Taber, Wendy Kohlmann, Samantha L. Leaf, Sancy Leachman

Research output: Contribution to journalArticle

20 Scopus citations


A major goal of predictive genetic testing is to alert people to their risk before illness onset; however, little is known about how risk perceptions change following genetic testing and whether information is recalled accurately over time. In the United States, a CDKN2A/p16 mutation confers 76 % lifetime risk of melanoma. Following genetic counseling and test reporting, subjective risk estimates and recall of counselor-provided risk estimates were assessed 5 times over the next 2 years among 60 adult members of 2 extended CDKN2A/p16 kindreds. No sustained changes from baseline in risk perceptions were reported. Unaffected carriers (n=15) consistently reported significantly lower subjective risk estimates (46 %) than they were actually given (76 %, p

Original languageEnglish (US)
Pages (from-to)421-437
Number of pages17
JournalJournal of Genetic Counseling
Issue number3
Publication statusPublished - 2014
Externally publishedYes



  • CDKN2A/p16
  • Genetic counseling
  • Genetic testing
  • Melanoma
  • Perceived risk

ASJC Scopus subject areas

  • Genetics(clinical)
  • Medicine(all)

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