Peptide YY(3-36) inhibits morning, but not evening, food intake and decreases body weight in rhesus macaques

Frank H. Koegler, Pablo J. Enriori, Sonja K. Billes, Diana L. Takahashi, Meghan S. Martin, Randall L. Clark, Anne E. Evans, Kevin L. Grove, Judy L. Cameron, Michael A. Cowley

    Research output: Contribution to journalArticle

    82 Scopus citations

    Abstract

    Peptide YY(3-36) [PYY(3-36)] is a hormone that is released after meal ingestion that is currently being investigated for the treatment of obesity; however, there are conflicting reports of the effects of PYY(3-36) on energy balance in rodent models. To shed light on this controversy, we studied the effect of PYY(3-36) on food intake and body weight in a nonhuman primate. Intravenous PYY(3-36) infusions before a morning meal transiently suppressed the rate of food intake but did not suppress the evening meal or 24-h intake. Twice-daily or continuous intravenous PYY(3-36) infusions to supraphysiological levels (levels that exceeded normal physiological levels) again suppressed the rate of feeding for the morning but not the evening meal. Twice-daily intravenous PYY (3-36) infusions for 2 weeks significantly decreased body weight in all test animals (average weight loss 1.9%) without changing insulin response to glucose infusion. These results show that endogenous PYY(3-36) may alter morning but not evening meal intake, and supraphysiological doses are required for effective suppression of food intake.

    Original languageEnglish (US)
    Pages (from-to)3198-3204
    Number of pages7
    JournalDiabetes
    Volume54
    Issue number11
    DOIs
    StatePublished - Nov 1 2005

    ASJC Scopus subject areas

    • Internal Medicine
    • Endocrinology, Diabetes and Metabolism

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    Koegler, F. H., Enriori, P. J., Billes, S. K., Takahashi, D. L., Martin, M. S., Clark, R. L., Evans, A. E., Grove, K. L., Cameron, J. L., & Cowley, M. A. (2005). Peptide YY(3-36) inhibits morning, but not evening, food intake and decreases body weight in rhesus macaques. Diabetes, 54(11), 3198-3204. https://doi.org/10.2337/diabetes.54.11.3198