Peptide therapy for anti-CD4 autoimmunity in HIV-1 infection: Toward the development of an autoimmune animal model

R. Abulafia-Lapid, M. Afentoulis, A. A. Vandenbark

Research output: Contribution to journalArticle

Abstract

Aiming to develop an animal model for anti-CD4 autoimmunity reflective of that observed in HIV-1 patients, we injected the selected peptides p1, p28 and p29 as the major immunogenic epitopes into HLA-DR4 and human CD4 transgenic DBA/16J mice, as well as into C57BL/6 and DBA mice. We document a decrease of CD4+ cells in peripheral blood and spleen after immunization with the human CD4-p28 immunogenic peptide of transgenic mice expressing human CD4, human HLA class II and mouse class II I-Aq (HLA-DR4-huCD4-I-Aq+); however, no decrease of CD4 cells was found in transgenic HLA-DR4-huCD4-I-Aq- mice or in control C57BL/6 and DBA immunized mice. Overall, the consistency of CD4 reduction and immunological recognition of p28 peptide favors the HLA-DR4-huCD4-I-Aq+ mouse as the most promising autoimmune mouse model.

Original languageEnglish (US)
Pages (from-to)3475-3480
Number of pages6
JournalVaccine
Volume27
Issue number25-26
DOIs
StatePublished - May 26 2009

Keywords

  • Anti-CD4 autoimmunity
  • HIV-1
  • Transgenic mice

ASJC Scopus subject areas

  • Molecular Medicine
  • Immunology and Microbiology(all)
  • veterinary(all)
  • Public Health, Environmental and Occupational Health
  • Infectious Diseases

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