Penetration of fluorescent particles in gelatin during laser thrombolysis

HanQun Shangguan, Lee W. Casperson, Kenton Gregory, Scott A. Prahl

Research output: Chapter in Book/Report/Conference proceedingConference contribution

2 Citations (Scopus)

Abstract

The use of pulsed laser energy to clear arteries obstructed by thrombus (blood clot) and plaque has emerged as a promising method for the treatment of cardiovascular diseases such as myocardial infarction and stroke. Current techniques for laser thrombolysis are limited because they cannot completely clear the clot in arteries, especially where a large volume clot is presented. Mural clot is a potent stimulus for reocclusion. We suggest that the combination of laser thrombolysis and localized intramural delivery of clot-dissolving drugs during the procedure may be a solution to this limitation. Ninety pulses of 30 - 70 mJ were delivered onto gelatin-based thrombus model with a flushing catheter. A solution of 1 micrometer fluorescent particles as a drug model was injected at a rate of 4 mL/min in coincidence with the laser delivery. The controls were performed by injecting drug after laser thrombolysis. We measured the penetration of the particles in gelatin and the sizes of the lumen and stained areas. The results of this study demonstrated the possibility of enhancing laser thrombolysis by delivering drugs into thrombus. It was found that the particles could be driven several hundred micron in gelatin, and the lumen areas would be increased up to 25% if the areas were dissolved by the drugs.

Original languageEnglish (US)
Title of host publicationProceedings of SPIE - The International Society for Optical Engineering
Pages10-18
Number of pages9
Volume2970
DOIs
StatePublished - 1997
EventLasers in Surgery: Advanced Characterization, Therapeutics, and Systems VII - San Jose, CA, United States
Duration: Feb 8 1997Feb 8 1997

Other

OtherLasers in Surgery: Advanced Characterization, Therapeutics, and Systems VII
CountryUnited States
CitySan Jose, CA
Period2/8/972/8/97

Fingerprint

Thrombolysis
gelatins
Gelatin
Penetration
Drugs
drugs
penetration
Laser
Lasers
lumens
Pharmaceutical Preparations
lasers
Arteries
arteries
delivery
myocardial infarction
flushing
Myocardial Infarction
Catheters
Pulsed Laser

Keywords

  • Laser thrombolysis
  • Laser-induced hydrodynamic pressure
  • Photomechanical drug delivery

ASJC Scopus subject areas

  • Applied Mathematics
  • Computer Science Applications
  • Electrical and Electronic Engineering
  • Electronic, Optical and Magnetic Materials
  • Condensed Matter Physics

Cite this

Shangguan, H., Casperson, L. W., Gregory, K., & Prahl, S. A. (1997). Penetration of fluorescent particles in gelatin during laser thrombolysis. In Proceedings of SPIE - The International Society for Optical Engineering (Vol. 2970, pp. 10-18) https://doi.org/10.1117/12.275030

Penetration of fluorescent particles in gelatin during laser thrombolysis. / Shangguan, HanQun; Casperson, Lee W.; Gregory, Kenton; Prahl, Scott A.

Proceedings of SPIE - The International Society for Optical Engineering. Vol. 2970 1997. p. 10-18.

Research output: Chapter in Book/Report/Conference proceedingConference contribution

Shangguan, H, Casperson, LW, Gregory, K & Prahl, SA 1997, Penetration of fluorescent particles in gelatin during laser thrombolysis. in Proceedings of SPIE - The International Society for Optical Engineering. vol. 2970, pp. 10-18, Lasers in Surgery: Advanced Characterization, Therapeutics, and Systems VII, San Jose, CA, United States, 2/8/97. https://doi.org/10.1117/12.275030
Shangguan H, Casperson LW, Gregory K, Prahl SA. Penetration of fluorescent particles in gelatin during laser thrombolysis. In Proceedings of SPIE - The International Society for Optical Engineering. Vol. 2970. 1997. p. 10-18 https://doi.org/10.1117/12.275030
Shangguan, HanQun ; Casperson, Lee W. ; Gregory, Kenton ; Prahl, Scott A. / Penetration of fluorescent particles in gelatin during laser thrombolysis. Proceedings of SPIE - The International Society for Optical Engineering. Vol. 2970 1997. pp. 10-18
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