Pediatric sleep apnea and craniofacial anomalies: A population-based case-control study

Derek Lam, Christine C. Jensen, Beth A. Mueller, Jacqueline R. Starr, Michael L. Cunningham, Edward M. Weaver

Research output: Contribution to journalArticle

36 Citations (Scopus)

Abstract

Objective: To investigate the association between craniofacial anomalies and diagnosis with obstructive sleep apnea (OSA) in a large, populationbased sample of children. Design: Retrospective case-control study. Methods: Cases of OSA (n = 1,203) were identified by International Classification of Diseases-9 codes consistent with OSA in the 1987-2003 Washington State inpatient discharge database among children ≤18 years of age and born in Washington state. For each case, five controls without OSA (n = 6,015) were randomly selected from the remaining Washington State births, frequency matched by birth year. Congenital anomaly diagnoses and covariates were extracted from discharge data for all inpatient hospitalizations during the study period and linked birth certificate data. Multiple logistic regression was used to calculate adjusted odds ratios (OR) and 95% confidence intervals (CI) for the associations between congenital anomalies (including subgroups) and OSA. Results: An OSA diagnosis was strongly associated with the presence of any craniofacial anomaly (adjusted OR 38, 95%CI [24, 60]) and, in particular, with orofacial cleft (adjusted OR 40, 95%CI [17, 94]) and Down syndrome (adjusted OR 51, 95%CI [20, 128]). OSA was less associated with any noncraniofacial malformation (adjusted OR 4.1, 95%CI [3.1, 5.3]), which may reflect the relatively small effect of inpatient exposure bias in the associations above. Conclusions: The presence of congenital craniofacial anomalies is strongly associated with inpatient diagnosis of OSA. These findings persist even after control of major potential biases. Parents and clinicians should consider screening for OSA among children with craniofacial anomalies.

Original languageEnglish (US)
Pages (from-to)2098-2105
Number of pages8
JournalLaryngoscope
Volume120
Issue number10
DOIs
StatePublished - Oct 2010
Externally publishedYes

Fingerprint

Sleep Apnea Syndromes
Obstructive Sleep Apnea
Case-Control Studies
Pediatrics
Population
Odds Ratio
Confidence Intervals
Inpatients
Parturition
Birth Certificates
International Classification of Diseases
Down Syndrome
Hospitalization
Parents
Logistic Models
Databases

Keywords

  • Craniofacial
  • Down syndrome
  • Orofacial cleft
  • Pediatric sleep apnea

ASJC Scopus subject areas

  • Otorhinolaryngology

Cite this

Lam, D., Jensen, C. C., Mueller, B. A., Starr, J. R., Cunningham, M. L., & Weaver, E. M. (2010). Pediatric sleep apnea and craniofacial anomalies: A population-based case-control study. Laryngoscope, 120(10), 2098-2105. https://doi.org/10.1002/lary.21093

Pediatric sleep apnea and craniofacial anomalies : A population-based case-control study. / Lam, Derek; Jensen, Christine C.; Mueller, Beth A.; Starr, Jacqueline R.; Cunningham, Michael L.; Weaver, Edward M.

In: Laryngoscope, Vol. 120, No. 10, 10.2010, p. 2098-2105.

Research output: Contribution to journalArticle

Lam, D, Jensen, CC, Mueller, BA, Starr, JR, Cunningham, ML & Weaver, EM 2010, 'Pediatric sleep apnea and craniofacial anomalies: A population-based case-control study', Laryngoscope, vol. 120, no. 10, pp. 2098-2105. https://doi.org/10.1002/lary.21093
Lam D, Jensen CC, Mueller BA, Starr JR, Cunningham ML, Weaver EM. Pediatric sleep apnea and craniofacial anomalies: A population-based case-control study. Laryngoscope. 2010 Oct;120(10):2098-2105. https://doi.org/10.1002/lary.21093
Lam, Derek ; Jensen, Christine C. ; Mueller, Beth A. ; Starr, Jacqueline R. ; Cunningham, Michael L. ; Weaver, Edward M. / Pediatric sleep apnea and craniofacial anomalies : A population-based case-control study. In: Laryngoscope. 2010 ; Vol. 120, No. 10. pp. 2098-2105.
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