TY - JOUR
T1 - Pediatric research priorities in healthcare-associated infections and antimicrobial stewardship
AU - Coffin, Susan E.
AU - Abanyie, Francisca
AU - Bryant, Kristina
AU - Cantey, Joseph
AU - Fiore, Anthony
AU - Fritz, Stephanie
AU - Guzman-Cottrill, Judith
AU - Hersh, Adam L.
AU - Huskins, W. Charles
AU - Kociolek, Larry K.
AU - Kronman, Matthew
AU - Lautenbach, Ebbing
AU - Lee, Grace
AU - Linam, Matthew
AU - Logan, Latania K.
AU - Milstone, Aaron
AU - Newland, Jason
AU - Nyquist, A. Christine
AU - Palazzi, Debra L.
AU - Patel, Sameer
AU - Puopolo, Karen
AU - Reddy, Sujan C.
AU - Saiman, Lisa
AU - Sandora, Thomas
AU - Shane, Andi L.
AU - Smith, Michael
AU - Tamma, Pranita D.
AU - Zaoutis, Theoklis
AU - Zerr, Danielle
AU - Gerber, Jeffrey S.
N1 - Funding Information:
K Bryant has received grant support from Pfizer. SE Coffin has received grant support from Merck, the CDC, and the NIH; she has also received royalties from UpToDate. S Fritz has received grant support from Merck, AHRQ, and the NIH. J Guzman-Cotrill has received payment for consultancy to the Oregon Health Authority. WC Huskins has received payment for consultancy to the ADMA Biologics and Pfizer. L Kociolek has received grant support from Merck. M Kronman has received grant support from the NIH. J Newland reports receiving grant support from Merck. D Palazzi reports receiving support for serving on boards for JAMA Pediatrics and AAP Prep ID, for consultancy to Pfizer, and royalties from UpToDate. S Patel reports receiving support for consultancy to Nexogen. K Puopolo reports receiving grant support from the NIH and CDC, royalties from UpToDate, and payment for development of educational materials for the VT-Oxford Network. A Shane reports receiving support for travel to meetings for the Pediatric Infectious Diseases Society and the World Society of Pediatric Infectious Diseases, and grant support from NIH and PCORI. D Zerr reports receiving grant support from Merck and royalties from UpToDate. All other authors have no conflicts to report related to this article.
Funding Information:
The Pediatric HAI and AS Research Priorities Project was support by the Prevention EpiCenters Program of the Centers for Disease Control and Prevention. All authors received support for air travel and housing to attend one in-person meeting in Atlanta.
Publisher Copyright:
©
PY - 2021/5
Y1 - 2021/5
N2 - Abstract Objective: To develop a pediatric research agenda focused on pediatric healthcare-associated infections and antimicrobial stewardship topics that will yield the highest impact on child health. Participants: The study included 26 geographically diverse adult and pediatric infectious diseases clinicians with expertise in healthcare-associated infection prevention and/or antimicrobial stewardship (topic identification and ranking of priorities), as well as members of the Division of Healthcare Quality and Promotion at the Centers for Disease Control and Prevention (topic identification). Methods: Using a modified Delphi approach, expert recommendations were generated through an iterative process for identifying pediatric research priorities in healthcare associated infection prevention and antimicrobial stewardship. The multistep, 7-month process included a literature review, interactive teleconferences, web-based surveys, and 2 in-person meetings. Results: A final list of 12 high-priority research topics were generated in the 2 domains. High-priority healthcare-associated infection topics included judicious testing for Clostridioides difficile infection, chlorhexidine (CHG) bathing, measuring and preventing hospital-onset bloodstream infection rates, surgical site infection prevention, surveillance and prevention of multidrug resistant gram-negative rod infections. Antimicrobial stewardship topics included β-lactam allergy de-labeling, judicious use of perioperative antibiotics, intravenous to oral conversion of antimicrobial therapy, developing a patient-level harm index for antibiotic exposure, and benchmarking and or peer comparison of antibiotic use for common inpatient conditions. Conclusions: We identified 6 healthcare-associated infection topics and 6 antimicrobial stewardship topics as potentially high-impact targets for pediatric research.
AB - Abstract Objective: To develop a pediatric research agenda focused on pediatric healthcare-associated infections and antimicrobial stewardship topics that will yield the highest impact on child health. Participants: The study included 26 geographically diverse adult and pediatric infectious diseases clinicians with expertise in healthcare-associated infection prevention and/or antimicrobial stewardship (topic identification and ranking of priorities), as well as members of the Division of Healthcare Quality and Promotion at the Centers for Disease Control and Prevention (topic identification). Methods: Using a modified Delphi approach, expert recommendations were generated through an iterative process for identifying pediatric research priorities in healthcare associated infection prevention and antimicrobial stewardship. The multistep, 7-month process included a literature review, interactive teleconferences, web-based surveys, and 2 in-person meetings. Results: A final list of 12 high-priority research topics were generated in the 2 domains. High-priority healthcare-associated infection topics included judicious testing for Clostridioides difficile infection, chlorhexidine (CHG) bathing, measuring and preventing hospital-onset bloodstream infection rates, surgical site infection prevention, surveillance and prevention of multidrug resistant gram-negative rod infections. Antimicrobial stewardship topics included β-lactam allergy de-labeling, judicious use of perioperative antibiotics, intravenous to oral conversion of antimicrobial therapy, developing a patient-level harm index for antibiotic exposure, and benchmarking and or peer comparison of antibiotic use for common inpatient conditions. Conclusions: We identified 6 healthcare-associated infection topics and 6 antimicrobial stewardship topics as potentially high-impact targets for pediatric research.
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U2 - 10.1017/ice.2020.1267
DO - 10.1017/ice.2020.1267
M3 - Article
C2 - 33239122
AN - SCOPUS:85096867421
VL - 42
SP - 519
EP - 522
JO - Infection Control and Hospital Epidemiology
JF - Infection Control and Hospital Epidemiology
SN - 0899-823X
IS - 5
ER -