Pediatric oncology enters an era of precision medicine

Nita L. Seibel, Katherine Janeway, Carl E. Allen, Susan N. Chi, Yoon-Jae Cho, Julia L. Glade Bender, Ae Rang Kim, Theodore W. Laetsch, Meredith S. Irwin, Naoko Takebe, James V. Tricoli, Donald Williams Parsons

Research output: Contribution to journalArticle

17 Scopus citations

Abstract

With the use of high-throughput molecular profiling technologies, precision medicine trials are ongoing for adults with cancer. Similarly, there is an interest in how these techniques can be applied to tumors in children and adolescents to expand our understanding of the biology of pediatric cancers and evaluate the clinical implications of genomic testing for these patients. This article reviews the early studies in pediatric oncology showing the feasibility of this approach, describe the future plans to evaluate the clinical implications in a multicenter clinical trial and identify the challenges of applying genomics in this patient population.

Original languageEnglish (US)
Pages (from-to)194-200
Number of pages7
JournalCurrent problems in cancer
Volume41
Issue number3
DOIs
StatePublished - May 1 2017

Keywords

  • Adolescent and young adult cancer
  • Genomic profiling
  • Next-generation sequencing
  • Pediatric tumors
  • RNA sequencing
  • Whole-exome sequencing

ASJC Scopus subject areas

  • Oncology
  • Cancer Research

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  • Cite this

    Seibel, N. L., Janeway, K., Allen, C. E., Chi, S. N., Cho, Y-J., Glade Bender, J. L., Kim, A. R., Laetsch, T. W., Irwin, M. S., Takebe, N., Tricoli, J. V., & Parsons, D. W. (2017). Pediatric oncology enters an era of precision medicine. Current problems in cancer, 41(3), 194-200. https://doi.org/10.1016/j.currproblcancer.2017.01.002