Pediatric low-grade gliomas

Kelly L. Collins, Ian F. Pollack

Research output: Contribution to journalReview articlepeer-review

2 Scopus citations

Abstract

Brain tumors constitute the largest source of oncologic mortality in children and lowgrade gliomas are among most common pediatric central nervous system tumors. Pediatric lowgrade gliomas differ from their counterparts in the adult population in their histopathology, genetics, and standard of care. Over the past decade, an increasingly detailed understanding of the molecular and genetic characteristics of pediatric brain tumors led to tailored therapy directed by integrated phenotypic and genotypic parameters and the availability of an increasing array of molecular-directed therapies. Advances in neuroimaging, conformal radiation therapy, and conventional chemotherapy further improved treatment outcomes. This article reviews the current classification of pediatric low-grade gliomas, their histopathologic and radiographic features, stateof-the-art surgical and adjuvant therapies, and emerging therapies currently under study in clinical trials.

Original languageEnglish (US)
Article number1152
JournalCancers
Volume12
Issue number5
DOIs
StatePublished - May 2020
Externally publishedYes

Keywords

  • BRAF mutation
  • Diffuse astrocytoma
  • Molecularly-targeted therapy
  • Neuroepithelial tumor
  • Pediatric low-grade glioma
  • Pilocytic astrocytoma
  • Pleomorphic xanthoastrocytoma
  • Subependymal giant cell astrocytoma

ASJC Scopus subject areas

  • Oncology
  • Cancer Research

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