PDX-MI

Minimal information for patient-derived tumor xenograft models

Terrence F. Meehan, Nathalie Conte, Theodore Goldstein, Giorgio Inghirami, Mark A. Murakami, Sebastian Brabetz, Zhiping Gu, Jeffrey A. Wiser, Patrick Dunn, Dale A. Begley, Debra M. Krupke, Andrea Bertotti, Alejandra Bruna, Matthew H. Brush, Annette T. Byrne, Carlos Caldas, Amanda L. Christie, Dominic A. Clark, Heidi Dowst, Jonathan R. Dry & 34 others James H. Doroshow, Olivier Duchamp, Yvonne A. Evrard, Stephane Ferretti, Kristopher K. Frese, Neal C. Goodwin, Danielle Greenawalt, Melissa Haendel, Els Hermans, Peter J. Houghton, Jos Jonkers, Kristel Kemper, Tin O. Khor, Michael T. Lewis, K. C.Kent Lloyd, Jeremy Mason, Enzo Medico, Steven B. Neuhauser, James M. Olson, Daniel S. Peeper, Oscar M. Rueda, Je Kyung Seong, Livio Trusolino, Emilie Vinolo, Robert J. Wechsler-Reya, David M. Weinstock, Alana Welm, S. John Weroha, Frédéric Amant, Stefan M. Pfister, Marcel Kool, Helen Parkinson, Atul J. Butte, Carol J. Bult

Research output: Contribution to journalArticle

14 Citations (Scopus)

Abstract

Patient-derived tumor xenograft (PDX) mouse models have emerged as an important oncology research platform to study tumor evolution, mechanisms of drug response and resistance, and tailoring chemotherapeutic approaches for individual patients. The lack of robust standards for reporting on PDX models has hampered the ability of researchers to find relevant PDX models and associated data. Here we present the PDX models minimal information standard (PDX-MI) for reporting on the generation, quality assurance, and use of PDX models. PDX-MI defines the minimal information for describing the clinical attributes of a patient's tumor, the processes of implantation and passaging of tumors in a host mouse strain, quality assurance methods, and the use of PDX models in cancer research. Adherence to PDX-MI standards will facilitate accurate search results for oncology models and their associated data across distributed repository databases and promote reproducibility in research studies using these models. Cancer Res; 77(21); e62-66.

Original languageEnglish (US)
Pages (from-to)e62-e66
JournalCancer Research
Volume77
Issue number21
DOIs
StatePublished - Nov 1 2017

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ASJC Scopus subject areas

  • Oncology
  • Cancer Research

Cite this

Meehan, T. F., Conte, N., Goldstein, T., Inghirami, G., Murakami, M. A., Brabetz, S., ... Bult, C. J. (2017). PDX-MI: Minimal information for patient-derived tumor xenograft models. Cancer Research, 77(21), e62-e66. https://doi.org/10.1158/0008-5472.CAN-17-0582

PDX-MI : Minimal information for patient-derived tumor xenograft models. / Meehan, Terrence F.; Conte, Nathalie; Goldstein, Theodore; Inghirami, Giorgio; Murakami, Mark A.; Brabetz, Sebastian; Gu, Zhiping; Wiser, Jeffrey A.; Dunn, Patrick; Begley, Dale A.; Krupke, Debra M.; Bertotti, Andrea; Bruna, Alejandra; Brush, Matthew H.; Byrne, Annette T.; Caldas, Carlos; Christie, Amanda L.; Clark, Dominic A.; Dowst, Heidi; Dry, Jonathan R.; Doroshow, James H.; Duchamp, Olivier; Evrard, Yvonne A.; Ferretti, Stephane; Frese, Kristopher K.; Goodwin, Neal C.; Greenawalt, Danielle; Haendel, Melissa; Hermans, Els; Houghton, Peter J.; Jonkers, Jos; Kemper, Kristel; Khor, Tin O.; Lewis, Michael T.; Lloyd, K. C.Kent; Mason, Jeremy; Medico, Enzo; Neuhauser, Steven B.; Olson, James M.; Peeper, Daniel S.; Rueda, Oscar M.; Seong, Je Kyung; Trusolino, Livio; Vinolo, Emilie; Wechsler-Reya, Robert J.; Weinstock, David M.; Welm, Alana; Weroha, S. John; Amant, Frédéric; Pfister, Stefan M.; Kool, Marcel; Parkinson, Helen; Butte, Atul J.; Bult, Carol J.

In: Cancer Research, Vol. 77, No. 21, 01.11.2017, p. e62-e66.

Research output: Contribution to journalArticle

Meehan, TF, Conte, N, Goldstein, T, Inghirami, G, Murakami, MA, Brabetz, S, Gu, Z, Wiser, JA, Dunn, P, Begley, DA, Krupke, DM, Bertotti, A, Bruna, A, Brush, MH, Byrne, AT, Caldas, C, Christie, AL, Clark, DA, Dowst, H, Dry, JR, Doroshow, JH, Duchamp, O, Evrard, YA, Ferretti, S, Frese, KK, Goodwin, NC, Greenawalt, D, Haendel, M, Hermans, E, Houghton, PJ, Jonkers, J, Kemper, K, Khor, TO, Lewis, MT, Lloyd, KCK, Mason, J, Medico, E, Neuhauser, SB, Olson, JM, Peeper, DS, Rueda, OM, Seong, JK, Trusolino, L, Vinolo, E, Wechsler-Reya, RJ, Weinstock, DM, Welm, A, Weroha, SJ, Amant, F, Pfister, SM, Kool, M, Parkinson, H, Butte, AJ & Bult, CJ 2017, 'PDX-MI: Minimal information for patient-derived tumor xenograft models', Cancer Research, vol. 77, no. 21, pp. e62-e66. https://doi.org/10.1158/0008-5472.CAN-17-0582
Meehan TF, Conte N, Goldstein T, Inghirami G, Murakami MA, Brabetz S et al. PDX-MI: Minimal information for patient-derived tumor xenograft models. Cancer Research. 2017 Nov 1;77(21):e62-e66. https://doi.org/10.1158/0008-5472.CAN-17-0582
Meehan, Terrence F. ; Conte, Nathalie ; Goldstein, Theodore ; Inghirami, Giorgio ; Murakami, Mark A. ; Brabetz, Sebastian ; Gu, Zhiping ; Wiser, Jeffrey A. ; Dunn, Patrick ; Begley, Dale A. ; Krupke, Debra M. ; Bertotti, Andrea ; Bruna, Alejandra ; Brush, Matthew H. ; Byrne, Annette T. ; Caldas, Carlos ; Christie, Amanda L. ; Clark, Dominic A. ; Dowst, Heidi ; Dry, Jonathan R. ; Doroshow, James H. ; Duchamp, Olivier ; Evrard, Yvonne A. ; Ferretti, Stephane ; Frese, Kristopher K. ; Goodwin, Neal C. ; Greenawalt, Danielle ; Haendel, Melissa ; Hermans, Els ; Houghton, Peter J. ; Jonkers, Jos ; Kemper, Kristel ; Khor, Tin O. ; Lewis, Michael T. ; Lloyd, K. C.Kent ; Mason, Jeremy ; Medico, Enzo ; Neuhauser, Steven B. ; Olson, James M. ; Peeper, Daniel S. ; Rueda, Oscar M. ; Seong, Je Kyung ; Trusolino, Livio ; Vinolo, Emilie ; Wechsler-Reya, Robert J. ; Weinstock, David M. ; Welm, Alana ; Weroha, S. John ; Amant, Frédéric ; Pfister, Stefan M. ; Kool, Marcel ; Parkinson, Helen ; Butte, Atul J. ; Bult, Carol J. / PDX-MI : Minimal information for patient-derived tumor xenograft models. In: Cancer Research. 2017 ; Vol. 77, No. 21. pp. e62-e66.
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abstract = "Patient-derived tumor xenograft (PDX) mouse models have emerged as an important oncology research platform to study tumor evolution, mechanisms of drug response and resistance, and tailoring chemotherapeutic approaches for individual patients. The lack of robust standards for reporting on PDX models has hampered the ability of researchers to find relevant PDX models and associated data. Here we present the PDX models minimal information standard (PDX-MI) for reporting on the generation, quality assurance, and use of PDX models. PDX-MI defines the minimal information for describing the clinical attributes of a patient's tumor, the processes of implantation and passaging of tumors in a host mouse strain, quality assurance methods, and the use of PDX models in cancer research. Adherence to PDX-MI standards will facilitate accurate search results for oncology models and their associated data across distributed repository databases and promote reproducibility in research studies using these models. Cancer Res; 77(21); e62-66.",
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AU - Meehan, Terrence F.

AU - Conte, Nathalie

AU - Goldstein, Theodore

AU - Inghirami, Giorgio

AU - Murakami, Mark A.

AU - Brabetz, Sebastian

AU - Gu, Zhiping

AU - Wiser, Jeffrey A.

AU - Dunn, Patrick

AU - Begley, Dale A.

AU - Krupke, Debra M.

AU - Bertotti, Andrea

AU - Bruna, Alejandra

AU - Brush, Matthew H.

AU - Byrne, Annette T.

AU - Caldas, Carlos

AU - Christie, Amanda L.

AU - Clark, Dominic A.

AU - Dowst, Heidi

AU - Dry, Jonathan R.

AU - Doroshow, James H.

AU - Duchamp, Olivier

AU - Evrard, Yvonne A.

AU - Ferretti, Stephane

AU - Frese, Kristopher K.

AU - Goodwin, Neal C.

AU - Greenawalt, Danielle

AU - Haendel, Melissa

AU - Hermans, Els

AU - Houghton, Peter J.

AU - Jonkers, Jos

AU - Kemper, Kristel

AU - Khor, Tin O.

AU - Lewis, Michael T.

AU - Lloyd, K. C.Kent

AU - Mason, Jeremy

AU - Medico, Enzo

AU - Neuhauser, Steven B.

AU - Olson, James M.

AU - Peeper, Daniel S.

AU - Rueda, Oscar M.

AU - Seong, Je Kyung

AU - Trusolino, Livio

AU - Vinolo, Emilie

AU - Wechsler-Reya, Robert J.

AU - Weinstock, David M.

AU - Welm, Alana

AU - Weroha, S. John

AU - Amant, Frédéric

AU - Pfister, Stefan M.

AU - Kool, Marcel

AU - Parkinson, Helen

AU - Butte, Atul J.

AU - Bult, Carol J.

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