PDGFRA Antibody for Soft Tissue Sarcoma

Lillian R. Klug, Michael C. Heinrich

    Research output: Contribution to journalShort surveypeer-review

    6 Scopus citations

    Abstract

    Lartruvo (olaratumab) is a monoclonal antibody against the extracellular domain of PDGFRA. Olaratumab blocks ligand binding and thereby inhibits activation of PDGFRA kinase activity. Pre-clinically, this antibody inhibited PDGFRA-dependent tumor growth. In a randomized Phase II study, adding olaratumab to doxorubicin chemotherapy significantly improved overall survival, leading to FDA approval.

    Original languageEnglish (US)
    Pages (from-to)555
    Number of pages1
    JournalCell
    Volume168
    Issue number4
    DOIs
    StatePublished - Feb 9 2017

    ASJC Scopus subject areas

    • Biochemistry, Genetics and Molecular Biology(all)

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