PD-1+ T-Cells Correlate with Nerve Fiber Density as a Prognostic Biomarker in Patients with Resected Perihilar Cholangiocarcinoma

Xiuxiang Tan; Jan Bednarsch; Mika Rosin; Simone Appinger; Dong Liu; Georg Wiltberger; Juan Garcia Vallejo; Sven Arke Lang; Zoltan Czigany; Shiva Boroojerdi; Nadine T. Gaisa; Peter Boor; Roman David Bülow; Judith De Vos-Geelen; Liselot Valkenburg-Van Iersel; Marian C. Clahsen-Van Groningen; Evelien J.M. de Jong; Bas Groot Koerkamp; Michail Doukas; Flavio G. Rocha; Tom Luedde; Uwe Klinge; Shivan Sivakumar; Ulf Peter Neumann; Lara Rosaline Heij

doi:10.3390/cancers14092190

PD-1+ T-Cells Correlate with Nerve Fiber Density as a Prognostic Biomarker in Patients with Resected Perihilar Cholangiocarcinoma

Xiuxiang Tan, Jan Bednarsch, Mika Rosin, Simone Appinger, Dong Liu, Georg Wiltberger, Juan Garcia Vallejo, Sven Arke Lang, Zoltan Czigany, Shiva Boroojerdi, Nadine T. Gaisa, Peter Boor, Roman David Bülow, Judith De Vos-Geelen, Liselot Valkenburg-Van Iersel, Marian C. Clahsen-Van Groningen, Evelien J.M. de Jong, Bas Groot Koerkamp, Michail Doukas, Flavio G. RochaTom Luedde, Uwe Klinge, Shivan Sivakumar, Ulf Peter Neumann, Lara Rosaline Heij

Research output: Contribution to journal › Article › peer-review

3 Scopus citations

Abstract

Background and Aims: Perihilar cholangiocarcinoma (pCCA) is a hepatobiliary malignancy, with a dismal prognosis. Nerve fiber density (NFD)—a novel prognostic biomarker—describes the density of small nerve fibers without cancer invasion and is categorized into high numbers and low numbers of small nerve fibers (high vs low NFD). NFD is different than perineural invasion (PNI),.

Original language	English (US)
Article number	2190
Journal	Cancers
Volume	14
Issue number	9
DOIs	https://doi.org/10.3390/cancers14092190
State	Published - May 1 2022

ASJC Scopus subject areas

Oncology
Cancer Research

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10.3390/cancers14092190

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Tan, X., Bednarsch, J., Rosin, M., Appinger, S., Liu, D., Wiltberger, G., Garcia Vallejo, J., Lang, S. A., Czigany, Z., Boroojerdi, S., Gaisa, N. T., Boor, P., Bülow, R. D., De Vos-Geelen, J., Valkenburg-Van Iersel, L., Clahsen-Van Groningen, M. C., de Jong, E. J. M., Koerkamp, B. G., Doukas, M., ... Heij, L. R. (2022). PD-1+ T-Cells Correlate with Nerve Fiber Density as a Prognostic Biomarker in Patients with Resected Perihilar Cholangiocarcinoma. Cancers, 14(9), Article 2190. https://doi.org/10.3390/cancers14092190

Tan, X, Bednarsch, J, Rosin, M, Appinger, S, Liu, D, Wiltberger, G, Garcia Vallejo, J, Lang, SA, Czigany, Z, Boroojerdi, S, Gaisa, NT, Boor, P, Bülow, RD, De Vos-Geelen, J, Valkenburg-Van Iersel, L, Clahsen-Van Groningen, MC, de Jong, EJM, Koerkamp, BG, Doukas, M, Rocha, FG, Luedde, T, Klinge, U, Sivakumar, S, Neumann, UP & Heij, LR 2022, 'PD-1+ T-Cells Correlate with Nerve Fiber Density as a Prognostic Biomarker in Patients with Resected Perihilar Cholangiocarcinoma', Cancers, vol. 14, no. 9, 2190. https://doi.org/10.3390/cancers14092190

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title = "PD-1+ T-Cells Correlate with Nerve Fiber Density as a Prognostic Biomarker in Patients with Resected Perihilar Cholangiocarcinoma",

abstract = "Background and Aims: Perihilar cholangiocarcinoma (pCCA) is a hepatobiliary malignancy, with a dismal prognosis. Nerve fiber density (NFD)—a novel prognostic biomarker—describes the density of small nerve fibers without cancer invasion and is categorized into high numbers and low numbers of small nerve fibers (high vs low NFD). NFD is different than perineural invasion (PNI),.",

author = "Xiuxiang Tan and Jan Bednarsch and Mika Rosin and Simone Appinger and Dong Liu and Georg Wiltberger and {Garcia Vallejo}, Juan and Lang, {Sven Arke} and Zoltan Czigany and Shiva Boroojerdi and Gaisa, {Nadine T.} and Peter Boor and B{\"u}low, {Roman David} and {De Vos-Geelen}, Judith and {Valkenburg-Van Iersel}, Liselot and {Clahsen-Van Groningen}, {Marian C.} and {de Jong}, {Evelien J.M.} and Koerkamp, {Bas Groot} and Michail Doukas and Rocha, {Flavio G.} and Tom Luedde and Uwe Klinge and Shivan Sivakumar and Neumann, {Ulf Peter} and Heij, {Lara Rosaline}",

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year = "2022",

month = may,

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doi = "10.3390/cancers14092190",

language = "English (US)",

volume = "14",

journal = "Cancers",

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T1 - PD-1+ T-Cells Correlate with Nerve Fiber Density as a Prognostic Biomarker in Patients with Resected Perihilar Cholangiocarcinoma

AU - Tan, Xiuxiang

AU - Bednarsch, Jan

AU - Rosin, Mika

AU - Appinger, Simone

AU - Liu, Dong

AU - Wiltberger, Georg

AU - Garcia Vallejo, Juan

AU - Lang, Sven Arke

AU - Czigany, Zoltan

AU - Boroojerdi, Shiva

AU - Gaisa, Nadine T.

AU - Boor, Peter

AU - Bülow, Roman David

AU - De Vos-Geelen, Judith

AU - Valkenburg-Van Iersel, Liselot

AU - Clahsen-Van Groningen, Marian C.

AU - de Jong, Evelien J.M.

AU - Koerkamp, Bas Groot

AU - Doukas, Michail

AU - Rocha, Flavio G.

AU - Luedde, Tom

AU - Klinge, Uwe

AU - Sivakumar, Shivan

AU - Neumann, Ulf Peter

AU - Heij, Lara Rosaline

N1 - Publisher Copyright: 2022 by the authors. Licensee MDPI, Basel, Switzerland.

PY - 2022/5/1

Y1 - 2022/5/1

N2 - Background and Aims: Perihilar cholangiocarcinoma (pCCA) is a hepatobiliary malignancy, with a dismal prognosis. Nerve fiber density (NFD)—a novel prognostic biomarker—describes the density of small nerve fibers without cancer invasion and is categorized into high numbers and low numbers of small nerve fibers (high vs low NFD). NFD is different than perineural invasion (PNI),.

AB - Background and Aims: Perihilar cholangiocarcinoma (pCCA) is a hepatobiliary malignancy, with a dismal prognosis. Nerve fiber density (NFD)—a novel prognostic biomarker—describes the density of small nerve fibers without cancer invasion and is categorized into high numbers and low numbers of small nerve fibers (high vs low NFD). NFD is different than perineural invasion (PNI),.

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PD-1+ T-Cells Correlate with Nerve Fiber Density as a Prognostic Biomarker in Patients with Resected Perihilar Cholangiocarcinoma

Abstract

ASJC Scopus subject areas

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