TY - JOUR
T1 - Patterns of recurrence after ablation of colorectal cancer liver metastases
AU - Kingham, T. Peter
AU - Tanoue, Michael
AU - Eaton, Anne
AU - Rocha, Flavio G.
AU - Do, Richard
AU - Allen, Peter
AU - De Matteo, Ronald P.
AU - D'Angelica, Michael
AU - Fong, Yuman
AU - Jarnagin, William R.
N1 - Copyright:
Copyright 2012 Elsevier B.V., All rights reserved.
PY - 2012/3
Y1 - 2012/3
N2 - Purpose. To determine the local recurrence rate and factors associated with recurrence after intraoperative ablation of colorectal cancer liver metastases. Methods. A retrospective analysis of a prospectively maintained database was performed for patients who underwent ablation of a hepatic colorectal cancer metastasis in the operating room from April 1996 to March 2010. Kaplan-Meier survival curves and Cox models were used to determine recurrence rates and assess significance. Results. Ablation was performed in 10% (n = 158 patients) of all cases during the study period. Seventy-eight percent were performed in conjunction with a liver resection. Of the 315 tumors ablated, most tumors were ≤1 cm in maximum diameter (53%). Radiofrequency ablation was used to treat most of the tumors (70%). Thirty-six tumors (11%) had local recurrence as part of their recurrence pattern. Disease recurred in the liver or systemically after 212 tumors (67%) were ablated. On univariate analysis, tumor size greater than 1 cm was associated with a significantly increased risk of local recurrence (hazard ratio 2.3, 95% confidence interval 1.2-4.5, P = 0.013). The 2 year ablation zone recurrence-free survival was 92% for tumors ≤1 cm compared to 81% for tumors >1 cm. On multivariate analysis, tumor size of >1 cm, lack of postoperative chemotherapy, and use of cryotherapy were significantly associated with a higher local recurrence rate. Conclusions. Intraoperative ablation appears to be highly effective treatment for hepatic colorectal tumors ≤1 cm.
AB - Purpose. To determine the local recurrence rate and factors associated with recurrence after intraoperative ablation of colorectal cancer liver metastases. Methods. A retrospective analysis of a prospectively maintained database was performed for patients who underwent ablation of a hepatic colorectal cancer metastasis in the operating room from April 1996 to March 2010. Kaplan-Meier survival curves and Cox models were used to determine recurrence rates and assess significance. Results. Ablation was performed in 10% (n = 158 patients) of all cases during the study period. Seventy-eight percent were performed in conjunction with a liver resection. Of the 315 tumors ablated, most tumors were ≤1 cm in maximum diameter (53%). Radiofrequency ablation was used to treat most of the tumors (70%). Thirty-six tumors (11%) had local recurrence as part of their recurrence pattern. Disease recurred in the liver or systemically after 212 tumors (67%) were ablated. On univariate analysis, tumor size greater than 1 cm was associated with a significantly increased risk of local recurrence (hazard ratio 2.3, 95% confidence interval 1.2-4.5, P = 0.013). The 2 year ablation zone recurrence-free survival was 92% for tumors ≤1 cm compared to 81% for tumors >1 cm. On multivariate analysis, tumor size of >1 cm, lack of postoperative chemotherapy, and use of cryotherapy were significantly associated with a higher local recurrence rate. Conclusions. Intraoperative ablation appears to be highly effective treatment for hepatic colorectal tumors ≤1 cm.
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U2 - 10.1245/s10434-011-2048-x
DO - 10.1245/s10434-011-2048-x
M3 - Article
C2 - 21879262
AN - SCOPUS:84862250177
SN - 1068-9265
VL - 19
SP - 834
EP - 841
JO - Annals of surgical oncology
JF - Annals of surgical oncology
IS - 3
ER -