Patterns of measles pneumonitis

Grace E. Radoycich, Craig W. Zuppan, Douglas Weeks, Henry F. Krous, Claire Langston

Research output: Contribution to journalArticle

11 Citations (Scopus)

Abstract

As a result of the enlarging pool of unvaccinated children and young adults, there has been an increase in serious measles pneumonitis in our areas. We recently examined autopsy and/or lung biopsy material from five children with fatal measles pneumonitis. Two patients were immunocompromised because of either prematurity or acute leukemia and died 13-16 days following onset of symptoms. Both had classic giant cell pneumonitis, with readily demonstrable intranuclear inclusions. Three other children without known immunocompromise had a more prolonged course. The lungs of these patients lacked the classic pattern and displayed instead a spectrum of less specific findings ranging from organizing diffuse alveolar damage to interstitial pneumonia with giant cells, but without viral inclusions. An accompanying necrotizing bronchiolitis was also present. Electron microscopy and/or detection of elevated measles-specific immunoglobulin M was necessary to confirm the diagnosis in these apparently immunocompetent patients. We conclude that the histologic features of fatal or serious measles pneumonitis are variable and depend to some extent on the immunocompetence of the host as well as the duration and tempo of the disease. Ancillary studies may be necessary to establish the diagnosis in cases lacking classic histopathologic features..

Original languageEnglish (US)
Pages (from-to)773-786
Number of pages14
JournalFetal and Pediatric Pathology
Volume12
Issue number6
DOIs
StatePublished - 1992
Externally publishedYes

Fingerprint

Measles
Pneumonia
Giant Cells
Immunocompetence
Intranuclear Inclusion Bodies
Lung
Bronchiolitis
Interstitial Lung Diseases
Immunocompromised Host
Immunoglobulin M
Young Adult
Autopsy
Electron Microscopy
Leukemia
Biopsy

Keywords

  • Children
  • Giant cell pneumonia
  • Measles
  • Pneumonia
  • Viral pneumonia

ASJC Scopus subject areas

  • Pathology and Forensic Medicine
  • Pediatrics, Perinatology, and Child Health

Cite this

Radoycich, G. E., Zuppan, C. W., Weeks, D., Krous, H. F., & Langston, C. (1992). Patterns of measles pneumonitis. Fetal and Pediatric Pathology, 12(6), 773-786. https://doi.org/10.3109/15513819209024234

Patterns of measles pneumonitis. / Radoycich, Grace E.; Zuppan, Craig W.; Weeks, Douglas; Krous, Henry F.; Langston, Claire.

In: Fetal and Pediatric Pathology, Vol. 12, No. 6, 1992, p. 773-786.

Research output: Contribution to journalArticle

Radoycich, GE, Zuppan, CW, Weeks, D, Krous, HF & Langston, C 1992, 'Patterns of measles pneumonitis', Fetal and Pediatric Pathology, vol. 12, no. 6, pp. 773-786. https://doi.org/10.3109/15513819209024234
Radoycich GE, Zuppan CW, Weeks D, Krous HF, Langston C. Patterns of measles pneumonitis. Fetal and Pediatric Pathology. 1992;12(6):773-786. https://doi.org/10.3109/15513819209024234
Radoycich, Grace E. ; Zuppan, Craig W. ; Weeks, Douglas ; Krous, Henry F. ; Langston, Claire. / Patterns of measles pneumonitis. In: Fetal and Pediatric Pathology. 1992 ; Vol. 12, No. 6. pp. 773-786.
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