Patterns of asymmetry do not change over the course of idiopathic parkinsonism: Implications for pathogenesis

C. S. Lee, M. Schulzer, E. Mak, John Hammerstad, S. Calne, D. B. Calne

Research output: Contribution to journalArticle

81 Citations (Scopus)

Abstract

Article abstract-We investigated the asymmetry of focal deficits of bradykinesia in a cross-sectional study of 198 patients with idiopathic parkinsonism. We have analyzed the difference in Unified Parkinson's Disease Rating Scale (UPDRS) scores between the more and less affected sides in these patients, whose duration of symptoms ranged from 1 to 15 years. There was no significant change in the asymmetry or focality over this period; the deficit for each side progressed faster initially and then approached the normal age-related linear rate of decline. Previous studies indicate that there is an inverse linear relation between the UPDRS bradykinesia score and the nigral dopaminergic cell count. We infer that the rate of death of nigral dopaminergic neurons is predetermined from the time of onset of pathogenesis. The simplest explanation is that a causal event kills some cells and damages others so that they undergo premature death. This sequence of changes could be implemented through environmental (toxic or viral) damage to the genome. Several diverse sources of evidence support this concept.

Original languageEnglish (US)
Pages (from-to)435-439
Number of pages5
JournalNeurology
Volume45
Issue number3
StatePublished - 1995
Externally publishedYes

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Hypokinesia
Parkinsonian Disorders
Substantia Nigra
Parkinson Disease
Premature Mortality
Poisons
Dopaminergic Neurons
Cell Count
Cross-Sectional Studies
Genome
Mortality

ASJC Scopus subject areas

  • Clinical Neurology

Cite this

Patterns of asymmetry do not change over the course of idiopathic parkinsonism : Implications for pathogenesis. / Lee, C. S.; Schulzer, M.; Mak, E.; Hammerstad, John; Calne, S.; Calne, D. B.

In: Neurology, Vol. 45, No. 3, 1995, p. 435-439.

Research output: Contribution to journalArticle

Lee, CS, Schulzer, M, Mak, E, Hammerstad, J, Calne, S & Calne, DB 1995, 'Patterns of asymmetry do not change over the course of idiopathic parkinsonism: Implications for pathogenesis', Neurology, vol. 45, no. 3, pp. 435-439.
Lee, C. S. ; Schulzer, M. ; Mak, E. ; Hammerstad, John ; Calne, S. ; Calne, D. B. / Patterns of asymmetry do not change over the course of idiopathic parkinsonism : Implications for pathogenesis. In: Neurology. 1995 ; Vol. 45, No. 3. pp. 435-439.
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