Patterns and predictors of successful treatment discontinuation in retinal vein occlusions with macular edema in the real world

Therlinder Lo, Daniella Lent-Schochet, Kieu Yen Luu, Ajay E. Kuriyan, Menachem Y. Weiss, Aleksandra V. Rachitskaya, Rishi P. Singh, Karen M. Wai, J. Peter Campbell, Kishan Gupta, Eric Nudleman, Kevin C. Chen, Glenn Yiu

Research output: Contribution to journalArticlepeer-review

Abstract

Background And Objective: To identify factors associated with successful treatment discontinuation in eyes with retinal vein occlusions (RVOs) and macular edema (ME) in real-world settings. Patients And Methods: Retrospective study of 214 eyes with RVO and ME with 24-month follow-up at five academic centers. Regression analyses identified factors associated with (1) successful treatment discontinuation for at least 6 months without fluid recurrence and (2) best-corrected visual acuity (BCVA) at 24 months. Results: Forty percent of eyes with branch RVO and 35% with central RVO (CRVO) / hemi-retinal RVO (HRVO) successfully discontinued therapy without fluid recurrence, with median time to discontinuation of 6 and 7 months, respectively. Lower 6-month central subfield thickness was associated with greater likelihood of treatment discontinuation within 24 months for eyes with CRVO/ HRVO (P = .001), whereas better 6-month BCVA was associated with better 24-month BCVA for all RVO subtypes (P < .001). Conclusion: Early anatomic response at 6 months is associated with greater likelihood of stopping treatments.

Original languageEnglish (US)
Pages (from-to)84-92
Number of pages9
JournalOphthalmic Surgery Lasers and Imaging Retina
Volume52
Issue number2
DOIs
StatePublished - Feb 2021

ASJC Scopus subject areas

  • Surgery
  • Ophthalmology

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