Patterns and predictors of successful treatment discontinuation in retinal vein occlusions with macular edema in the real world

Therlinder Lo; Daniella Lent-Schochet; Kieu Yen Luu; Ajay E. Kuriyan; Menachem Y. Weiss; Aleksandra V. Rachitskaya; Rishi P. Singh; Karen M. Wai; J. Peter Campbell; Kishan Gupta; Eric Nudleman; Kevin C. Chen; Glenn Yiu

doi:10.3928/23258160-20210201-05

Patterns and predictors of successful treatment discontinuation in retinal vein occlusions with macular edema in the real world

Therlinder Lo, Daniella Lent-Schochet, Kieu Yen Luu, Ajay E. Kuriyan, Menachem Y. Weiss, Aleksandra V. Rachitskaya, Rishi P. Singh, Karen M. Wai, J. Peter Campbell, Kishan Gupta, Eric Nudleman, Kevin C. Chen, Glenn Yiu

Ophthalmology

Research output: Contribution to journal › Article › peer-review

3 Scopus citations

Abstract

Background And Objective: To identify factors associated with successful treatment discontinuation in eyes with retinal vein occlusions (RVOs) and macular edema (ME) in real-world settings. Patients And Methods: Retrospective study of 214 eyes with RVO and ME with 24-month follow-up at five academic centers. Regression analyses identified factors associated with (1) successful treatment discontinuation for at least 6 months without fluid recurrence and (2) best-corrected visual acuity (BCVA) at 24 months. Results: Forty percent of eyes with branch RVO and 35% with central RVO (CRVO) / hemi-retinal RVO (HRVO) successfully discontinued therapy without fluid recurrence, with median time to discontinuation of 6 and 7 months, respectively. Lower 6-month central subfield thickness was associated with greater likelihood of treatment discontinuation within 24 months for eyes with CRVO/ HRVO (P = .001), whereas better 6-month BCVA was associated with better 24-month BCVA for all RVO subtypes (P < .001). Conclusion: Early anatomic response at 6 months is associated with greater likelihood of stopping treatments.

Original language	English (US)
Pages (from-to)	84-92
Number of pages	9
Journal	Ophthalmic Surgery Lasers and Imaging Retina
Volume	52
Issue number	2
DOIs	https://doi.org/10.3928/23258160-20210201-05
State	Published - Feb 2021

ASJC Scopus subject areas

Surgery
Ophthalmology

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Lo, T., Lent-Schochet, D., Luu, K. Y., Kuriyan, A. E., Weiss, M. Y., Rachitskaya, A. V., Singh, R. P., Wai, K. M., Campbell, J. P., Gupta, K., Nudleman, E., Chen, K. C., & Yiu, G. (2021). Patterns and predictors of successful treatment discontinuation in retinal vein occlusions with macular edema in the real world. Ophthalmic Surgery Lasers and Imaging Retina, 52(2), 84-92. https://doi.org/10.3928/23258160-20210201-05

Lo, T, Lent-Schochet, D, Luu, KY, Kuriyan, AE, Weiss, MY, Rachitskaya, AV, Singh, RP, Wai, KM, Campbell, JP, Gupta, K, Nudleman, E, Chen, KC & Yiu, G 2021, 'Patterns and predictors of successful treatment discontinuation in retinal vein occlusions with macular edema in the real world', Ophthalmic Surgery Lasers and Imaging Retina, vol. 52, no. 2, pp. 84-92. https://doi.org/10.3928/23258160-20210201-05

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title = "Patterns and predictors of successful treatment discontinuation in retinal vein occlusions with macular edema in the real world",

abstract = "Background And Objective: To identify factors associated with successful treatment discontinuation in eyes with retinal vein occlusions (RVOs) and macular edema (ME) in real-world settings. Patients And Methods: Retrospective study of 214 eyes with RVO and ME with 24-month follow-up at five academic centers. Regression analyses identified factors associated with (1) successful treatment discontinuation for at least 6 months without fluid recurrence and (2) best-corrected visual acuity (BCVA) at 24 months. Results: Forty percent of eyes with branch RVO and 35% with central RVO (CRVO) / hemi-retinal RVO (HRVO) successfully discontinued therapy without fluid recurrence, with median time to discontinuation of 6 and 7 months, respectively. Lower 6-month central subfield thickness was associated with greater likelihood of treatment discontinuation within 24 months for eyes with CRVO/ HRVO (P = .001), whereas better 6-month BCVA was associated with better 24-month BCVA for all RVO subtypes (P < .001). Conclusion: Early anatomic response at 6 months is associated with greater likelihood of stopping treatments.",

author = "Therlinder Lo and Daniella Lent-Schochet and Luu, {Kieu Yen} and Kuriyan, {Ajay E.} and Weiss, {Menachem Y.} and Rachitskaya, {Aleksandra V.} and Singh, {Rishi P.} and Wai, {Karen M.} and Campbell, {J. Peter} and Kishan Gupta and Eric Nudleman and Chen, {Kevin C.} and Glenn Yiu",

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AU - Lo, Therlinder

AU - Lent-Schochet, Daniella

AU - Luu, Kieu Yen

AU - Kuriyan, Ajay E.

AU - Weiss, Menachem Y.

AU - Rachitskaya, Aleksandra V.

AU - Singh, Rishi P.

AU - Wai, Karen M.

AU - Campbell, J. Peter

AU - Gupta, Kishan

AU - Nudleman, Eric

AU - Chen, Kevin C.

AU - Yiu, Glenn

PY - 2021/2

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N2 - Background And Objective: To identify factors associated with successful treatment discontinuation in eyes with retinal vein occlusions (RVOs) and macular edema (ME) in real-world settings. Patients And Methods: Retrospective study of 214 eyes with RVO and ME with 24-month follow-up at five academic centers. Regression analyses identified factors associated with (1) successful treatment discontinuation for at least 6 months without fluid recurrence and (2) best-corrected visual acuity (BCVA) at 24 months. Results: Forty percent of eyes with branch RVO and 35% with central RVO (CRVO) / hemi-retinal RVO (HRVO) successfully discontinued therapy without fluid recurrence, with median time to discontinuation of 6 and 7 months, respectively. Lower 6-month central subfield thickness was associated with greater likelihood of treatment discontinuation within 24 months for eyes with CRVO/ HRVO (P = .001), whereas better 6-month BCVA was associated with better 24-month BCVA for all RVO subtypes (P < .001). Conclusion: Early anatomic response at 6 months is associated with greater likelihood of stopping treatments.

AB - Background And Objective: To identify factors associated with successful treatment discontinuation in eyes with retinal vein occlusions (RVOs) and macular edema (ME) in real-world settings. Patients And Methods: Retrospective study of 214 eyes with RVO and ME with 24-month follow-up at five academic centers. Regression analyses identified factors associated with (1) successful treatment discontinuation for at least 6 months without fluid recurrence and (2) best-corrected visual acuity (BCVA) at 24 months. Results: Forty percent of eyes with branch RVO and 35% with central RVO (CRVO) / hemi-retinal RVO (HRVO) successfully discontinued therapy without fluid recurrence, with median time to discontinuation of 6 and 7 months, respectively. Lower 6-month central subfield thickness was associated with greater likelihood of treatment discontinuation within 24 months for eyes with CRVO/ HRVO (P = .001), whereas better 6-month BCVA was associated with better 24-month BCVA for all RVO subtypes (P < .001). Conclusion: Early anatomic response at 6 months is associated with greater likelihood of stopping treatments.

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Patterns and predictors of successful treatment discontinuation in retinal vein occlusions with macular edema in the real world

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