Patterned expression of Purkinje cell glutamate transporters controls synaptic plasticity

Jacques I. Wadiche, Craig E. Jahr

Research output: Contribution to journalArticle

153 Scopus citations

Abstract

Glutamate transporters are responsible for clearing synaptically released glutamate from the extracellular space. If expressed at high enough densities, transporters can prevent activation of extrasynaptic receptors by rapidly lowering glutamate concentrations to insignificant levels. We find that synaptic activation of metabotropic glutamate receptors expressed by Purkinje cells is prevented in regions of rat cerebellum where the density of the glutamate transporter EAAT4 is high. The consequences of metabotropic receptor stimulation, including activation of a depolarizing conductance, cannabinoid-mediated presynaptic inhibition and long-term depression, are also limited in Purkinje cells expressing high levels of EAAT4. We conclude that neuronal uptake sites must be overwhelmed by glutamate to activate perisynaptic metabotropic glutamate receptors. Regional differences in glutamate transporter expression affect the degree of metabotropic glutamate receptor activation and therefore regulate synaptic plasticity.

Original languageEnglish (US)
Pages (from-to)1329-1334
Number of pages6
JournalNature Neuroscience
Volume8
Issue number10
DOIs
StatePublished - Oct 1 2005

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ASJC Scopus subject areas

  • Neuroscience(all)

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