Patients with Fanconi anemia and AML have different cytogenetic clones than de novo cases of AML

Andrzej Rochowski, Susan B. Olson, Todd A. Alonzo, Robert B. Gerbing, Beverly J. Lange, Blanche P. Alter

Research output: Contribution to journalArticle

18 Scopus citations

Abstract

Specific cytogenetic clones might distinguish patients with unrecognized Fanconi anemia (FA) who present with acute myeloid leukemia (AML) from those with sporadic AML. Cytogenetic reports in literature cases of FA and AML were compared with de novo cases enrolled on CCG-2961. Gain of 1q, gain of 3q, monosomy 7, deleted 7q, gain of 13q, and deleted 20q were more frequent in FA AML; t(8;21), trisomy 8, t(9;11), t(6;9), and inversion 16 were exclusive to de novo AML cases. Observation of the FA AML cytogenetic clonal patterns should raise suspicion of an underlying leukemia predisposition syndrome and influence management.

Original languageEnglish (US)
Pages (from-to)922-924
Number of pages3
JournalPediatric Blood and Cancer
Volume59
Issue number5
DOIs
StatePublished - Nov 1 2012

Keywords

  • Acute myelogenous leukemia
  • Clones
  • Cytogenetics
  • Fanconi anemia
  • Sporadic AML

ASJC Scopus subject areas

  • Pediatrics, Perinatology, and Child Health
  • Hematology
  • Oncology

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