Patient-specific time-varying association between spatial and temporal variability in repolarization and high sensitivity troponin i

Larisa Tereshchenko, Albert Feeny

    Research output: Chapter in Book/Report/Conference proceedingConference contribution

    Abstract

    We hypothesized that the patient-specific time-varying changes in the spatial and temporal variability in cardiac repolarization (quantified by spatial TT' angle), and in myocardial injury (measured by high sensitivity troponin I, hsTnI), are independently associated with each other. Spatial TT' angle on resting 12-lead ECG (transformed to vectorcardiogram) and hsTnI were measured simultaneously every 3 hours during a 12-hour observation period in a prospective cohort of emergency department patients (n=379; age 57.8±13.2y; 54% female, 64% black), diagnosed with acute coronary syndrome (ACS; n=28), acute decompensated heart failure (ADHF; n=35), or an acute non-cardiac condition (n=316). High (above median) HsTnI in ACS was characterized by significantly larger TT' angle (12±8 vs 5±2 degrees; P=0.01) 12 hours after admission, but not earlier. In adjusted multinomial logit model, spatial TT' angle was associated with ADHF (Relative Risk Ratio 6.24 (95%CI 1.32-29.57; P=0.021), but not ACS. After full adjustment for confounders in random-effect linear regression, a 10 fold increase in hsTnI in a specific study participant was associated with 1.05 (95%CI 0.19-1.92) degrees increase in spatial TT' angle. Longitudinal association of hsTnI and TT' angle was especially prominent in patients with acute non-cardiac conditions, but not in ACS or ADHF.

    Original languageEnglish (US)
    Title of host publicationComputing in Cardiology Conference, CinC 2016
    PublisherIEEE Computer Society
    Pages333-336
    Number of pages4
    Volume43
    ISBN (Electronic)9781509008964
    StatePublished - Mar 1 2017
    Event43rd Computing in Cardiology Conference, CinC 2016 - Vancouver, Canada
    Duration: Sep 11 2016Sep 14 2016

    Other

    Other43rd Computing in Cardiology Conference, CinC 2016
    CountryCanada
    CityVancouver
    Period9/11/169/14/16

    Fingerprint

    Troponin
    Troponin I
    Electrocardiography
    Linear regression
    Lead
    Acute Coronary Syndrome
    Hospital Emergency Service
    Linear Models
    Heart Failure
    Logistic Models
    Odds Ratio
    Observation
    Wounds and Injuries

    ASJC Scopus subject areas

    • Computer Science(all)
    • Cardiology and Cardiovascular Medicine

    Cite this

    Tereshchenko, L., & Feeny, A. (2017). Patient-specific time-varying association between spatial and temporal variability in repolarization and high sensitivity troponin i. In Computing in Cardiology Conference, CinC 2016 (Vol. 43, pp. 333-336). [7868747] IEEE Computer Society.

    Patient-specific time-varying association between spatial and temporal variability in repolarization and high sensitivity troponin i. / Tereshchenko, Larisa; Feeny, Albert.

    Computing in Cardiology Conference, CinC 2016. Vol. 43 IEEE Computer Society, 2017. p. 333-336 7868747.

    Research output: Chapter in Book/Report/Conference proceedingConference contribution

    Tereshchenko, L & Feeny, A 2017, Patient-specific time-varying association between spatial and temporal variability in repolarization and high sensitivity troponin i. in Computing in Cardiology Conference, CinC 2016. vol. 43, 7868747, IEEE Computer Society, pp. 333-336, 43rd Computing in Cardiology Conference, CinC 2016, Vancouver, Canada, 9/11/16.
    Tereshchenko L, Feeny A. Patient-specific time-varying association between spatial and temporal variability in repolarization and high sensitivity troponin i. In Computing in Cardiology Conference, CinC 2016. Vol. 43. IEEE Computer Society. 2017. p. 333-336. 7868747
    Tereshchenko, Larisa ; Feeny, Albert. / Patient-specific time-varying association between spatial and temporal variability in repolarization and high sensitivity troponin i. Computing in Cardiology Conference, CinC 2016. Vol. 43 IEEE Computer Society, 2017. pp. 333-336
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