Patient perspectives on physician conflict of interest in industry-sponsored clinical trials for multiple sclerosis therapeutics

Andrew J. Solomon, Eran P. Klein, John R. Corboy, James L. Bernat

Research output: Chapter in Book/Report/Conference proceedingChapter

1 Scopus citations

Abstract

BACKGROUND: Pharmaceutical industry financial support of physicians, physician practices, and academic departments involved in multicenter industry-sponsored clinical trials of novel therapeutic agents is a relatively new and infrequently acknowledged source of potential physician conflict of interest. Detailed disclosure of these relationships to study participants is not uniformly a part of informed consent and documentation practices. OBJECTIVE: To understand attitudes of patients with multiple sclerosis concerning disclosure of potential physician-industry conflicts of interest created by clinical trials and how such disclosures may influence study participation METHODS: An anonymous online instrument was developed. RESULTS: 597 people with multiple sclerosis participated in the study. The study found that detailed disclosure of conflicts of interest is important to potential participants in industry-sponsored clinical trials for multiple sclerosis therapies and that the presence of these conflicts of interest may influence patients' decisions to participate in these studies. CONCLUSIONS: Findings from this study support a call for uniform guidelines regarding disclosure of physician-industry relationships to prospective research participants for industry-sponsored clinical trials.

Original languageEnglish (US)
Title of host publicationGetting to Good
Subtitle of host publicationResearch Integrity in the Biomedical Sciences
PublisherSpringer International Publishing
Pages498-506
Number of pages9
ISBN (Electronic)9783319513584
ISBN (Print)9783319513577
DOIs
StatePublished - Jul 23 2018

Keywords

  • Clinical trials
  • Conflict of interest
  • Industry-sponsored clinical trials
  • Multiple sclerosis
  • Professional conduct and ethics

ASJC Scopus subject areas

  • Medicine(all)

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    Solomon, A. J., Klein, E. P., Corboy, J. R., & Bernat, J. L. (2018). Patient perspectives on physician conflict of interest in industry-sponsored clinical trials for multiple sclerosis therapeutics. In Getting to Good: Research Integrity in the Biomedical Sciences (pp. 498-506). Springer International Publishing. https://doi.org/10.1177/1352458515569101