@article{641dbab3c00a47a3b24a31ff64ae5cd3,
title = "Pathways to cures for multiple sclerosis: A research roadmap",
abstract = "Background: Multiple Sclerosis (MS) is a growing global health challenge affecting nearly 3 million people. Progress has been made in the understanding and treatment of MS over the last several decades, but cures remain elusive. The National MS Society is focused on achieving cures for MS. Objectives: Cures for MS will be hastened by having a roadmap that describes knowledge gaps, milestones, and research priorities. In this report, we share the Pathways to Cures Research Roadmap and recommendations for strategies to accelerate the development of MS cures. Methods: The Roadmap was developed through engagement of scientific thought leaders and people affected by MS from North America and the United Kingdom. It also included the perspectives of over 300 people living with MS and was endorsed by many leading MS organizations. Results: The Roadmap consist of three distinct but overlapping cure pathways: (1) stopping the MS disease process, (2) restoring lost function by reversing damage and symptoms, and (3) ending MS through prevention. Better alignment and focus of global resources on high priority research questions are also recommended. Conclusions: We hope the Roadmap will inspire greater collaboration and alignment of global resources that accelerate scientific breakthroughs leading to cures for MS.",
keywords = "Multiple sclerosis, global health, knowledge gaps, patient advocacy, research priorities",
author = "Bebo, {Bruce F.} and Mark Allegretta and Douglas Landsman and Zackowski, {Kathy M.} and Fiona Brabazon and Kostich, {Walter A.} and Timothy Coetzee and Ng, {Alexander Victor} and Marrie, {Ruth Ann} and Monk, {Kelly R.} and Amit Bar-Or and Whitacre, {Caroline C.}",
note = "Funding Information: The author(s) declared the following potential conflicts of interest with respect to the research, authorship, and/or publication of this article: Bruce Bebo, Mark Allegretta, Douglas Landsman, Kathy Zackowski, Fiona Brabazon, Walter Kostich, and Timothy Coetzee are employees of the National MS Society and have no other relevant conflicts to disclose. Alexander Ng has no relevant conflicts to disclose. Ruth Ann Marrie is a co-investigator on a study funded by Roche and Biogen (no funds to Dr. Marrie or her institution). Kelly Monk has no relevant conflicts to disclose. Amit Bar-Or has received research grants and consulting fees from Biogen, grants, and consulting fees from Genetech/Roche, consulting fees from GlaxoSmithKlein, research grants and consulting fees from Merck/EMD Serono, consulting fees from Medimmune, research grants and consulting fees from Novartis, consulting fees from Celgene/Receptos, consulting fees from Sanofi-Genzyme, consulting fees from Atara Biotherapeutics, and Jansen/Actelion. None of these disclosures are related to this work. Caroline Whitacre has no relevant conflicts to disclose. Funding Information: The author(s) disclosed receipt of the following financial support for the research, authorship, and/or publication of this article: Activities supporting the development of the Roadmap were funded by the National Multiple Sclerosis Society. Publisher Copyright: {\textcopyright} The Author(s), 2022.",
year = "2022",
month = mar,
doi = "10.1177/13524585221075990",
language = "English (US)",
volume = "28",
pages = "331--345",
journal = "Multiple Sclerosis",
issn = "1352-4585",
publisher = "SAGE Publications Ltd",
number = "3",
}