Pathophysiology of pyoderma gangrenosum (PG)

An updated review

Sara F. Braswell, Tassia C. Kostopoulos, Alex Ortega Loayza

Research output: Contribution to journalReview article

78 Citations (Scopus)

Abstract

Pyoderma gangrenosum is a challenging skin condition to identify and treat because of its multifactorial pathogenesis. It is a rare cutaneous manifestation diagnosed clinically by exclusion of infection, neoplasia, thrombophilia, and other inflammatory conditions. Pathogenetic and treatment studies are scarce. Abnormalities in the function of inflammatory cytokines, the immune system, and neutrophils combined with specific genetic mutations predispose patients to develop this complex disease process. Early recognition of patients at risk for pyoderma gangrenosum, the necessity to improve its early diagnosis, and the future outlook of targeted and personalized therapies relies on the improved comprehension of the complex pathogenesis of pyoderma gangrenosum.

Original languageEnglish (US)
Pages (from-to)691-698
Number of pages8
JournalJournal of the American Academy of Dermatology
Volume73
Issue number4
DOIs
StatePublished - Oct 1 2015
Externally publishedYes

Fingerprint

Pyoderma Gangrenosum
Skin Manifestations
Thrombophilia
Early Diagnosis
Immune System
Neutrophils
Cytokines
Skin
Mutation
Therapeutics
Infection
Neoplasms

Keywords

  • Cytokines
  • Genetics
  • Inflammation
  • Neutrophilic dermatoses
  • Pathogenesis
  • Pyoderma gangrenosum

ASJC Scopus subject areas

  • Dermatology

Cite this

Pathophysiology of pyoderma gangrenosum (PG) : An updated review. / Braswell, Sara F.; Kostopoulos, Tassia C.; Ortega Loayza, Alex.

In: Journal of the American Academy of Dermatology, Vol. 73, No. 4, 01.10.2015, p. 691-698.

Research output: Contribution to journalReview article

Braswell, Sara F. ; Kostopoulos, Tassia C. ; Ortega Loayza, Alex. / Pathophysiology of pyoderma gangrenosum (PG) : An updated review. In: Journal of the American Academy of Dermatology. 2015 ; Vol. 73, No. 4. pp. 691-698.
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