Pathophysiology of pyoderma gangrenosum (PG): An updated review

Sara F. Braswell, Tassia C. Kostopoulos, Alex G. Ortega-Loayza

Research output: Contribution to journalReview article

94 Scopus citations

Abstract

Pyoderma gangrenosum is a challenging skin condition to identify and treat because of its multifactorial pathogenesis. It is a rare cutaneous manifestation diagnosed clinically by exclusion of infection, neoplasia, thrombophilia, and other inflammatory conditions. Pathogenetic and treatment studies are scarce. Abnormalities in the function of inflammatory cytokines, the immune system, and neutrophils combined with specific genetic mutations predispose patients to develop this complex disease process. Early recognition of patients at risk for pyoderma gangrenosum, the necessity to improve its early diagnosis, and the future outlook of targeted and personalized therapies relies on the improved comprehension of the complex pathogenesis of pyoderma gangrenosum.

Original languageEnglish (US)
Pages (from-to)691-698
Number of pages8
JournalJournal of the American Academy of Dermatology
Volume73
Issue number4
DOIs
StatePublished - Oct 1 2015

Keywords

  • Cytokines
  • Genetics
  • Inflammation
  • Neutrophilic dermatoses
  • Pathogenesis
  • Pyoderma gangrenosum

ASJC Scopus subject areas

  • Dermatology

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