TY - JOUR
T1 - Pathophysiology of psoriasis
T2 - Recent advances on IL-23 and TH17 cytokines
AU - Fitch, Erin
AU - Harper, Erin
AU - Skorcheva, Iliyana
AU - Kurtz, Stephen E.
AU - Blauvelt, Andrew
PY - 2007/12
Y1 - 2007/12
N2 - T helper (Th) 17 cells, a novel T-cell subset, have been implicated in the pathogenesis of psoriasis and other autoimmune inflammatory diseases. Interleukin (IL)-23 stimulates survival and proliferation of Th17 cells, and thus serves as a key master cytokine regulator for these diseases. In psoriasis, IL-23 is overproduced by dendritic cells and keratinocytes, and this cytokine stimulates Th17 cells within dermis to make IL-17A and 1L-22. IL-22, in particular, drives keratinocyte hyperproliferation in psoriasis. Future targeting of these key cytokines is likely to lead to dramatic clinical improvement in patients with psoriasis. This review focuses on the numerous recent studies on the roles of IL-23 and Th17 cells in the pathogenesis of psoriasis.
AB - T helper (Th) 17 cells, a novel T-cell subset, have been implicated in the pathogenesis of psoriasis and other autoimmune inflammatory diseases. Interleukin (IL)-23 stimulates survival and proliferation of Th17 cells, and thus serves as a key master cytokine regulator for these diseases. In psoriasis, IL-23 is overproduced by dendritic cells and keratinocytes, and this cytokine stimulates Th17 cells within dermis to make IL-17A and 1L-22. IL-22, in particular, drives keratinocyte hyperproliferation in psoriasis. Future targeting of these key cytokines is likely to lead to dramatic clinical improvement in patients with psoriasis. This review focuses on the numerous recent studies on the roles of IL-23 and Th17 cells in the pathogenesis of psoriasis.
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U2 - 10.1007/s11926-007-0075-1
DO - 10.1007/s11926-007-0075-1
M3 - Review article
C2 - 18177599
AN - SCOPUS:37349131221
SN - 1523-3774
VL - 9
SP - 461
EP - 467
JO - Current rheumatology reports
JF - Current rheumatology reports
IS - 6
ER -