Pathology of pulmonary hypertension

Rubin M. Tuder, Elvira Stacher, Jeffrey Robinson, Rahul Kumar, Brian B. Graham

Research output: Contribution to journalReview articlepeer-review

88 Scopus citations

Abstract

The pathology of pulmonary hypertension includes numerous abnormalities of the intima, media, and adventitia of the pulmonary vascular tree. A recently completed systematic analysis revealed high variability of morphologic measurements within a given pulmonary arterial hypertension (PAH) lung and among all PAH lungs, as well as distinct pathologic subphenotypes, and included a subset of lungs lacking intimal and medial remodeling. There was correlation between perivascular inflammation, remodeling, and hemodynamics. This article summarizes the pathologic features of the normal and abnormal pulmonary circulation, and correlations with animal models.

Original languageEnglish (US)
Pages (from-to)639-650
Number of pages12
JournalClinics in Chest Medicine
Volume34
Issue number4
DOIs
StatePublished - Dec 2013
Externally publishedYes

Keywords

  • Angiogenesis
  • Endothelial cells
  • Pulmonary hypertension
  • Smooth muscle cells
  • Vascular remodeling

ASJC Scopus subject areas

  • Pulmonary and Respiratory Medicine

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