Pathology and biology associated with the fragile FHIT gene and gene product

Joshua C. Saldivar, Hidetaka Shibata, Kay Huebner

Research output: Contribution to journalReview articlepeer-review

40 Scopus citations

Abstract

More than 12 years and >800 scientific publications after the discovery of the first gene at a chromosome fragile site, the FHIT gene at FRA3B, there are still questions to pursue concerning the selective advantage conferred to cells by loss of expression of FHIT, the most frequent target of allele deletion in precancerous lesions and cancers. These questions are considered in light of recent investigations of genetic and epigenetic alterations to the locus and in a retrospective consideration of biological roles of the Fhit protein discovered through functional studies.

Original languageEnglish (US)
Pages (from-to)858-865
Number of pages8
JournalJournal of cellular biochemistry
Volume109
Issue number5
DOIs
StatePublished - Apr 1 2010
Externally publishedYes

Keywords

  • Common fragile sites
  • DNA damage checkpoint
  • DNA repair
  • FHIT
  • Promoter methylation

ASJC Scopus subject areas

  • Biochemistry
  • Molecular Biology
  • Cell Biology

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