Pathogenesis of Bronchiectasis

Research output: Contribution to journalReview article

28 Scopus citations

Abstract

The pathogenesis of bronchiectasis cannot be explained by a single cause. The current model is a vicious cycle of inflammation and altered response to infection. This cycle depends not only on the type and virulence of the pathogen but also on the host immune response. In this response, too much or too little can damage the airways or fail to clear the pathogen, thus increasing the probability of further infection. This review describes the changes and advancement in the pathogenesis of bronchiectasis, including mechanisms of injury and host factors.

Original languageEnglish (US)
Pages (from-to)211-217
Number of pages7
JournalClinics in Chest Medicine
Volume33
Issue number2
DOIs
StatePublished - Jun 1 2012

Keywords

  • Airway epithelium
  • Bronchiectasis
  • Pathogenesis
  • Sputum

ASJC Scopus subject areas

  • Pulmonary and Respiratory Medicine

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