Pathobiology Of HIV/SIV-Associated Changes In Secondary Lymphoid Tissues

Research output: Contribution to journalArticle

48 Citations (Scopus)

Abstract

Acquired immunodeficiency syndrome (AIDS) is principally a disease of lymphoid tissues (LTs), due to the fact that the main target cell of human immunodeficiency virus (HIV) is the CD4+ T lymphocyte that primarily resides within organs of the immune system. The impact of HIV infection on secondary LTs, in particular lymph nodes, is critical to delineate, as these immune organs are the principal sites for initiating and facilitating immune responses and are critical for lymphocyte homeostatic maintenance and survival. The underlying structural elements of LTs, fibroblastic reticular cell (FRC) network, not only form the architectural framework for these organs, but also play in integral role in the production and storage of cytokines needed for T-cell survival. There is an interdependent relationship between the FRC stromal network and CD4+ T lymphocytes for their survival and maintenance that is progressively disrupted during HIV disease. HIV infection results in profound pathological changes to LTs induced by persistent chronic immune activation and inflammation that leads to progressive collagen deposition and fibrosis disrupting and damaging the important FRC network. In this review, I focus on the process, mechanisms, and the implications of pathological damage to important secondary LTs, combining what we have learned from HIV-infected individuals as well as the invaluable knowledge gained from studies in non-human primate simian immunodeficiency virus infection models.

Original languageEnglish (US)
Pages (from-to)65-77
Number of pages13
JournalImmunological Reviews
Volume254
Issue number1
DOIs
StatePublished - Jul 1 2013
Externally publishedYes

Fingerprint

Lymphoid Tissue
Virus Diseases
HIV
T-Lymphocytes
Primate Lentiviruses
Maintenance
Simian Immunodeficiency Virus
Stromal Cells
Immune System
Cell Survival
Acquired Immunodeficiency Syndrome
Fibrosis
Collagen
Lymph Nodes
Lymphocytes
Cytokines
Inflammation

Keywords

  • AIDS
  • Fibrosis
  • Inflammation
  • Lymph nodes
  • T cells

ASJC Scopus subject areas

  • Immunology
  • Immunology and Allergy

Cite this

Pathobiology Of HIV/SIV-Associated Changes In Secondary Lymphoid Tissues. / Estes, Jacob.

In: Immunological Reviews, Vol. 254, No. 1, 01.07.2013, p. 65-77.

Research output: Contribution to journalArticle

@article{35474fb0e1984591917e0a4862790df0,
title = "Pathobiology Of HIV/SIV-Associated Changes In Secondary Lymphoid Tissues",
abstract = "Acquired immunodeficiency syndrome (AIDS) is principally a disease of lymphoid tissues (LTs), due to the fact that the main target cell of human immunodeficiency virus (HIV) is the CD4+ T lymphocyte that primarily resides within organs of the immune system. The impact of HIV infection on secondary LTs, in particular lymph nodes, is critical to delineate, as these immune organs are the principal sites for initiating and facilitating immune responses and are critical for lymphocyte homeostatic maintenance and survival. The underlying structural elements of LTs, fibroblastic reticular cell (FRC) network, not only form the architectural framework for these organs, but also play in integral role in the production and storage of cytokines needed for T-cell survival. There is an interdependent relationship between the FRC stromal network and CD4+ T lymphocytes for their survival and maintenance that is progressively disrupted during HIV disease. HIV infection results in profound pathological changes to LTs induced by persistent chronic immune activation and inflammation that leads to progressive collagen deposition and fibrosis disrupting and damaging the important FRC network. In this review, I focus on the process, mechanisms, and the implications of pathological damage to important secondary LTs, combining what we have learned from HIV-infected individuals as well as the invaluable knowledge gained from studies in non-human primate simian immunodeficiency virus infection models.",
keywords = "AIDS, Fibrosis, Inflammation, Lymph nodes, T cells",
author = "Jacob Estes",
year = "2013",
month = "7",
day = "1",
doi = "10.1111/imr.12070",
language = "English (US)",
volume = "254",
pages = "65--77",
journal = "Immunological Reviews",
issn = "0105-2896",
publisher = "Wiley-Blackwell",
number = "1",

}

TY - JOUR

T1 - Pathobiology Of HIV/SIV-Associated Changes In Secondary Lymphoid Tissues

AU - Estes, Jacob

PY - 2013/7/1

Y1 - 2013/7/1

N2 - Acquired immunodeficiency syndrome (AIDS) is principally a disease of lymphoid tissues (LTs), due to the fact that the main target cell of human immunodeficiency virus (HIV) is the CD4+ T lymphocyte that primarily resides within organs of the immune system. The impact of HIV infection on secondary LTs, in particular lymph nodes, is critical to delineate, as these immune organs are the principal sites for initiating and facilitating immune responses and are critical for lymphocyte homeostatic maintenance and survival. The underlying structural elements of LTs, fibroblastic reticular cell (FRC) network, not only form the architectural framework for these organs, but also play in integral role in the production and storage of cytokines needed for T-cell survival. There is an interdependent relationship between the FRC stromal network and CD4+ T lymphocytes for their survival and maintenance that is progressively disrupted during HIV disease. HIV infection results in profound pathological changes to LTs induced by persistent chronic immune activation and inflammation that leads to progressive collagen deposition and fibrosis disrupting and damaging the important FRC network. In this review, I focus on the process, mechanisms, and the implications of pathological damage to important secondary LTs, combining what we have learned from HIV-infected individuals as well as the invaluable knowledge gained from studies in non-human primate simian immunodeficiency virus infection models.

AB - Acquired immunodeficiency syndrome (AIDS) is principally a disease of lymphoid tissues (LTs), due to the fact that the main target cell of human immunodeficiency virus (HIV) is the CD4+ T lymphocyte that primarily resides within organs of the immune system. The impact of HIV infection on secondary LTs, in particular lymph nodes, is critical to delineate, as these immune organs are the principal sites for initiating and facilitating immune responses and are critical for lymphocyte homeostatic maintenance and survival. The underlying structural elements of LTs, fibroblastic reticular cell (FRC) network, not only form the architectural framework for these organs, but also play in integral role in the production and storage of cytokines needed for T-cell survival. There is an interdependent relationship between the FRC stromal network and CD4+ T lymphocytes for their survival and maintenance that is progressively disrupted during HIV disease. HIV infection results in profound pathological changes to LTs induced by persistent chronic immune activation and inflammation that leads to progressive collagen deposition and fibrosis disrupting and damaging the important FRC network. In this review, I focus on the process, mechanisms, and the implications of pathological damage to important secondary LTs, combining what we have learned from HIV-infected individuals as well as the invaluable knowledge gained from studies in non-human primate simian immunodeficiency virus infection models.

KW - AIDS

KW - Fibrosis

KW - Inflammation

KW - Lymph nodes

KW - T cells

UR - http://www.scopus.com/inward/record.url?scp=84879302220&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=84879302220&partnerID=8YFLogxK

U2 - 10.1111/imr.12070

DO - 10.1111/imr.12070

M3 - Article

C2 - 23772615

AN - SCOPUS:84879302220

VL - 254

SP - 65

EP - 77

JO - Immunological Reviews

JF - Immunological Reviews

SN - 0105-2896

IS - 1

ER -