Patch-test results of the North American Contact Dermatitis Group 2005-2006

Kathryn A. Zug, Erin M. Warshaw, Joseph F. Fowler, Howard I. Maibach, Donald L. Belsito, Melanie D. Pratt, Denis Sasseville, Frances Storrs, James S. Taylor, C. G Toby Mathias, Vincent A. DeLeo, Robert L. Rietschel

Research output: Contribution to journalArticle

205 Citations (Scopus)

Abstract

Background: The North American Contact Dermatitis Group (NACDG) tests patients who have suspected allergic contact dermatitis with a broad series of screening allergens, and publishes periodic reports of its data. Objective: To report the NACDG patch-test results from January 1, 2005, to December 31, 2006, and to compare results to pooled test data from the previous 10 years. Methods: Standardized patch testing with 65 allergens was used at 13 centers in North America. Chi-square statistics were utilized for comparisons with previous NACDG data. Results: NACDG patch-tested 4,454 patients; 12.3% (557) had an occupation-related skin condition, and 65.3% (2,907) had at least one allergic patch-test reaction. The 15 most frequently positive allergens were nickel sulfate (19.0%), Myroxilon pereirae (balsam of Peru, 11.9%), fragrance mix I (11.5%), quaternium-15 (10.3%), neomycin (10.0%), bacitracin (9.2%), formaldehyde (9.0%), cobalt chloride (8.4%), methyldibromoglutaronitrile/ phenoxyethanol (5.8%), p-phenylenediamine (5.0%), potassium dichromate (4.8%), carba mix (3.9%), thiuram mix (3.9%), diazolidinylurea (3.7%), and 2-bromo-2-nitropropane-1,3-diol (3.4%). As compared to the 1994-2004 data, there were significant increases in rates of positivity to nickel, quaternium-15, potassium dichromate, lidocaine, and tea tree oil. Of patch-tested patients, 22.9% (1,019) had a relevant positive reaction to a supplementary allergen; 4.9% (219) had an occupationally relevant positive reaction to a supplementary allergen. Conclusion: Nickel has been the most frequently positive allergen detected by the NACDG; rates significantly increased in the current study period and most reactions were clinically relevant. Other common allergens were topical antibiotics, preservatives, fragrance mix I and paraphenylenediamine. Testing with an expanded allergen series and supplementary allergens enhances detection of relevant positive allergens.

Original languageEnglish (US)
Pages (from-to)149-160
Number of pages12
JournalDermatitis
Volume20
Issue number3
DOIs
StatePublished - May 2009
Externally publishedYes

Fingerprint

Patch Tests
Contact Dermatitis
Allergens
Potassium Dichromate
Nickel
Tea Tree Oil
Thiram
Bacitracin
Allergic Contact Dermatitis
Neomycin
North America
Lidocaine
Occupations
Formaldehyde
Anti-Bacterial Agents
Skin

ASJC Scopus subject areas

  • Dermatology
  • Immunology and Allergy

Cite this

Zug, K. A., Warshaw, E. M., Fowler, J. F., Maibach, H. I., Belsito, D. L., Pratt, M. D., ... Rietschel, R. L. (2009). Patch-test results of the North American Contact Dermatitis Group 2005-2006. Dermatitis, 20(3), 149-160. https://doi.org/10.2310/6620.2009.08097

Patch-test results of the North American Contact Dermatitis Group 2005-2006. / Zug, Kathryn A.; Warshaw, Erin M.; Fowler, Joseph F.; Maibach, Howard I.; Belsito, Donald L.; Pratt, Melanie D.; Sasseville, Denis; Storrs, Frances; Taylor, James S.; Mathias, C. G Toby; DeLeo, Vincent A.; Rietschel, Robert L.

In: Dermatitis, Vol. 20, No. 3, 05.2009, p. 149-160.

Research output: Contribution to journalArticle

Zug, KA, Warshaw, EM, Fowler, JF, Maibach, HI, Belsito, DL, Pratt, MD, Sasseville, D, Storrs, F, Taylor, JS, Mathias, CGT, DeLeo, VA & Rietschel, RL 2009, 'Patch-test results of the North American Contact Dermatitis Group 2005-2006', Dermatitis, vol. 20, no. 3, pp. 149-160. https://doi.org/10.2310/6620.2009.08097
Zug KA, Warshaw EM, Fowler JF, Maibach HI, Belsito DL, Pratt MD et al. Patch-test results of the North American Contact Dermatitis Group 2005-2006. Dermatitis. 2009 May;20(3):149-160. https://doi.org/10.2310/6620.2009.08097
Zug, Kathryn A. ; Warshaw, Erin M. ; Fowler, Joseph F. ; Maibach, Howard I. ; Belsito, Donald L. ; Pratt, Melanie D. ; Sasseville, Denis ; Storrs, Frances ; Taylor, James S. ; Mathias, C. G Toby ; DeLeo, Vincent A. ; Rietschel, Robert L. / Patch-test results of the North American Contact Dermatitis Group 2005-2006. In: Dermatitis. 2009 ; Vol. 20, No. 3. pp. 149-160.
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abstract = "Background: The North American Contact Dermatitis Group (NACDG) tests patients who have suspected allergic contact dermatitis with a broad series of screening allergens, and publishes periodic reports of its data. Objective: To report the NACDG patch-test results from January 1, 2005, to December 31, 2006, and to compare results to pooled test data from the previous 10 years. Methods: Standardized patch testing with 65 allergens was used at 13 centers in North America. Chi-square statistics were utilized for comparisons with previous NACDG data. Results: NACDG patch-tested 4,454 patients; 12.3{\%} (557) had an occupation-related skin condition, and 65.3{\%} (2,907) had at least one allergic patch-test reaction. The 15 most frequently positive allergens were nickel sulfate (19.0{\%}), Myroxilon pereirae (balsam of Peru, 11.9{\%}), fragrance mix I (11.5{\%}), quaternium-15 (10.3{\%}), neomycin (10.0{\%}), bacitracin (9.2{\%}), formaldehyde (9.0{\%}), cobalt chloride (8.4{\%}), methyldibromoglutaronitrile/ phenoxyethanol (5.8{\%}), p-phenylenediamine (5.0{\%}), potassium dichromate (4.8{\%}), carba mix (3.9{\%}), thiuram mix (3.9{\%}), diazolidinylurea (3.7{\%}), and 2-bromo-2-nitropropane-1,3-diol (3.4{\%}). As compared to the 1994-2004 data, there were significant increases in rates of positivity to nickel, quaternium-15, potassium dichromate, lidocaine, and tea tree oil. Of patch-tested patients, 22.9{\%} (1,019) had a relevant positive reaction to a supplementary allergen; 4.9{\%} (219) had an occupationally relevant positive reaction to a supplementary allergen. Conclusion: Nickel has been the most frequently positive allergen detected by the NACDG; rates significantly increased in the current study period and most reactions were clinically relevant. Other common allergens were topical antibiotics, preservatives, fragrance mix I and paraphenylenediamine. Testing with an expanded allergen series and supplementary allergens enhances detection of relevant positive allergens.",
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AU - Zug, Kathryn A.

AU - Warshaw, Erin M.

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AU - Belsito, Donald L.

AU - Pratt, Melanie D.

AU - Sasseville, Denis

AU - Storrs, Frances

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N2 - Background: The North American Contact Dermatitis Group (NACDG) tests patients who have suspected allergic contact dermatitis with a broad series of screening allergens, and publishes periodic reports of its data. Objective: To report the NACDG patch-test results from January 1, 2005, to December 31, 2006, and to compare results to pooled test data from the previous 10 years. Methods: Standardized patch testing with 65 allergens was used at 13 centers in North America. Chi-square statistics were utilized for comparisons with previous NACDG data. Results: NACDG patch-tested 4,454 patients; 12.3% (557) had an occupation-related skin condition, and 65.3% (2,907) had at least one allergic patch-test reaction. The 15 most frequently positive allergens were nickel sulfate (19.0%), Myroxilon pereirae (balsam of Peru, 11.9%), fragrance mix I (11.5%), quaternium-15 (10.3%), neomycin (10.0%), bacitracin (9.2%), formaldehyde (9.0%), cobalt chloride (8.4%), methyldibromoglutaronitrile/ phenoxyethanol (5.8%), p-phenylenediamine (5.0%), potassium dichromate (4.8%), carba mix (3.9%), thiuram mix (3.9%), diazolidinylurea (3.7%), and 2-bromo-2-nitropropane-1,3-diol (3.4%). As compared to the 1994-2004 data, there were significant increases in rates of positivity to nickel, quaternium-15, potassium dichromate, lidocaine, and tea tree oil. Of patch-tested patients, 22.9% (1,019) had a relevant positive reaction to a supplementary allergen; 4.9% (219) had an occupationally relevant positive reaction to a supplementary allergen. Conclusion: Nickel has been the most frequently positive allergen detected by the NACDG; rates significantly increased in the current study period and most reactions were clinically relevant. Other common allergens were topical antibiotics, preservatives, fragrance mix I and paraphenylenediamine. Testing with an expanded allergen series and supplementary allergens enhances detection of relevant positive allergens.

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