Passive neutralizing antibody controls SHIV viremia and enhances B cell responses in infant macaques

Cherie T. Ng, J. Pablo Jaworski, Pushpa Jayaraman, William F. Sutton, Patrick Delio, Larene Kuller, David Anderson, Gary Landucci, Barbra A. Richardson, Dennis R. Burton, Donald N. Forthal, Nancy Haigwood

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    104 Scopus citations

    Abstract

    Maternal HIV-1-specific antibodies are efficiently transferred to newborns, but their role in disease control is unknown. We administered neutralizing IgG, including the human neutralizing monoclonal IgG1b12, at levels insufficient to block infection, to six newborn macaques before oral challenge with simian-HIV strain SF162P3 (SHIVSF162P3). All of the macaques rapidly developed neutralizing antibodies and had significantly reduced plasma viremia for six months. These studies support the use of neutralizing antibodies in enhancing B cell responses and viral control in perinatal settings.

    Original languageEnglish (US)
    Pages (from-to)1117-1119
    Number of pages3
    JournalNature Medicine
    Volume16
    Issue number10
    DOIs
    Publication statusPublished - Oct 2010

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    ASJC Scopus subject areas

    • Biochemistry, Genetics and Molecular Biology(all)
    • Medicine(all)

    Cite this

    Ng, C. T., Jaworski, J. P., Jayaraman, P., Sutton, W. F., Delio, P., Kuller, L., ... Haigwood, N. (2010). Passive neutralizing antibody controls SHIV viremia and enhances B cell responses in infant macaques. Nature Medicine, 16(10), 1117-1119. https://doi.org/10.1038/nm.2233