@article{8b1e5c4498584994a6627d0dc9612a44,
title = "Passive neutralizing antibody controls SHIV viremia and enhances B cell responses in infant macaques",
abstract = "Maternal HIV-1-specific antibodies are efficiently transferred to newborns, but their role in disease control is unknown. We administered neutralizing IgG, including the human neutralizing monoclonal IgG1b12, at levels insufficient to block infection, to six newborn macaques before oral challenge with simian-HIV strain SF162P3 (SHIVSF162P3). All of the macaques rapidly developed neutralizing antibodies and had significantly reduced plasma viremia for six months. These studies support the use of neutralizing antibodies in enhancing B cell responses and viral control in perinatal settings.",
author = "Ng, {Cherie T.} and Jaworski, {J. Pablo} and Pushpa Jayaraman and Sutton, {William F.} and Patrick Delio and Larene Kuller and David Anderson and Gary Landucci and Richardson, {Barbra A.} and Burton, {Dennis R.} and Forthal, {Donald N.} and Haigwood, {Nancy L.}",
note = "Funding Information: We would like to thank Z. Brower for technical support, D. Morris and K. Filer for manuscript preparation, M.L. Marthas and K.K.A. Van Rompay for advice on subcutaneous dosing of IgG and oral inoculation of infants, J. Overbaugh (Fred Hutchinson Cancer Research Center) for the Env-deleted viral backbone plasmid Q23ΔEnv, S. Barnett and I. Srinivasan (Novartis) for recombinant gp120-SF162 and V. Planelles (University of Utah) for the plasmid pEMC*. M. Piatak and J.D. Lifson (Science Applications International Corporation) kindly provided RNA standards and advice on real-time PCR. SHIVSF162P3 was supplied by N. Miller (US National Institutes of Health Division of AIDS) and R. Pal (Advanced Bioscience Labs). TZM-bl were supplied by the US National Institutes of Health AIDS Research Reference Reagent Program. This study was supported by grants from the US National Institutes of Health R01HD038653 (N.L.H.), R01AI33292 (D.R.B.) and R01AI052039 (D.N.F.) and from the Elizabeth Glaser Pediatric AIDS Foundation (N.L.H.).",
year = "2010",
month = oct,
doi = "10.1038/nm.2233",
language = "English (US)",
volume = "16",
pages = "1117--1119",
journal = "Nature medicine",
issn = "1078-8956",
publisher = "Nature Publishing Group",
number = "10",
}