Passage through mitosis is required for oncoretroviruses but not for the human immunodeficiency virus

P. F. Lewis, M. Emerman

Research output: Contribution to journalComment/debate

619 Scopus citations


The human immunodeficiency virus productively infects and integrates into cells that have been arrested in the cell cycle with either gamma irradiation or aphidicolin. Integration by oncoretroviruses such as the murine leukemia virus (MuLV), on the other hand, depends on cell proliferation. Although the entire cell cycle is not necessary for MuLV infection, it is essential that the infected cells pass through mitosis. The long terminal repeat circle junction, a marker for nuclear entry, is first observed in MuLV-infected cells immediately after mitosis. These results suggest that mitosis is necessary for nuclear entry of MuLV, but not human immunodeficiency virus, unintegrated proviral DNA.

Original languageEnglish (US)
Pages (from-to)510-516
Number of pages7
JournalJournal of virology
Issue number1
StatePublished - Jan 1 1994


ASJC Scopus subject areas

  • Microbiology
  • Immunology
  • Insect Science
  • Virology

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