Passage through mitosis is required for oncoretroviruses but not for the human immunodeficiency virus

Paul Lewis, Michael Emerman

Research output: Contribution to journalArticle

608 Citations (Scopus)

Abstract

The human immunodeficiency virus productively infects and integrates into cells that have been arrested in the cell cycle with either gamma irradiation or aphidicolin. Integration by oncoretroviruses such as the murine leukemia virus (MuLV), on the other hand, depends on cell proliferation. Although the entire cell cycle is not necessary for MuLV infection, it is essential that the infected cells pass through mitosis. The long terminal repeat circle junction, a marker for nuclear entry, is first observed in MuLV-infected cells immediately after mitosis. These results suggest that mitosis is necessary for nuclear entry of MuLV, but not human immunodeficiency virus, unintegrated proviral DNA.

Original languageEnglish (US)
Pages (from-to)510-516
Number of pages7
JournalJournal of Virology
Volume68
Issue number1
StatePublished - Jan 1994
Externally publishedYes

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Murine leukemia virus
Murine Leukemia Viruses
Human immunodeficiency virus
Mitosis
mitosis
HIV
cell cycle
Cell Cycle
Aphidicolin
terminal repeat sequences
Terminal Repeat Sequences
Virus Diseases
cells
gamma radiation
cell proliferation
Cell Proliferation
DNA
infection

ASJC Scopus subject areas

  • Immunology

Cite this

Passage through mitosis is required for oncoretroviruses but not for the human immunodeficiency virus. / Lewis, Paul; Emerman, Michael.

In: Journal of Virology, Vol. 68, No. 1, 01.1994, p. 510-516.

Research output: Contribution to journalArticle

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