Partnerships for Drug Repositioning: Lessons from the CTSA Pharmaceutical Assets Portal

Kate Marusina, Dean J. Welsch, Lynn Rose, Doug Brock, Nathan Bahr, Aaron M. Cohen, Rafael A. Gacel-Sinclair, Pakou Vang, Peter G. Ruminski, Bruce E. Bloom, Pamela Nagasawa, Betty P. Guo

Research output: Chapter in Book/Report/Conference proceedingChapter

Abstract

Drug repositioning, or finding new uses for existing compounds, is a novel approach to drug development, with great potential for reducing the time and cost of bringing a new treatment to the market. The mission of the CTSA Pharmaceutical Assets Portal has been to facilitate collaborations between industry and academic investigators for discovery of new indications for compounds that are no longer being actively developed by pharmaceutical companies. While the ultimate goal of creating a shared repository accessible to the academic community remains to be achieved, to date, the Pharma Portal has created an infrastructure that includes a national database of principal investigators with their respective biological models and delivery systems; a foci-of-expertise collaboration tool; a facility to house and maintain a compound repository; and a funding partner for repositioning studies. In summary, the Pharma Portal has created a strategy and a mechanism to support future opportunities for public-private partnerships in drug repositioning.

Original languageEnglish (US)
Title of host publicationCollaborative Innovation in Drug Discovery
Subtitle of host publicationStrategies for Public and Private Partnerships
PublisherWiley-Blackwell
Pages115-133
Number of pages19
ISBN (Electronic)9781118778166
ISBN (Print)9780470917374
DOIs
StatePublished - Apr 14 2014

Keywords

  • CTSA
  • Drug discovery
  • Pharmaceutical
  • Repositioning
  • Repurposing

ASJC Scopus subject areas

  • Medicine(all)
  • Pharmacology, Toxicology and Pharmaceutics(all)
  • Chemistry(all)
  • Engineering(all)
  • Biochemistry, Genetics and Molecular Biology(all)

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  • Cite this

    Marusina, K., Welsch, D. J., Rose, L., Brock, D., Bahr, N., Cohen, A. M., Gacel-Sinclair, R. A., Vang, P., Ruminski, P. G., Bloom, B. E., Nagasawa, P., & Guo, B. P. (2014). Partnerships for Drug Repositioning: Lessons from the CTSA Pharmaceutical Assets Portal. In Collaborative Innovation in Drug Discovery: Strategies for Public and Private Partnerships (pp. 115-133). Wiley-Blackwell. https://doi.org/10.1002/9781118778166.ch9